Latent tuberculosis among adult Ethiopian patients at chest clinic, Tikuranbessa specialized hospital, Addis Ababa, Ethiopia
Ethiop. med. j. (Online)
; 54(4): 181-188, 2016. ilus
Article
in Fr
| AIM
| ID: biblio-1261976
Responsible library:
CG1.1
ABSTRACT
Background:
One-third of the world population is infected with mycobacterium tuberculosis. Most people exposed to mycobacterium tuberculosis showed no evidence of active disease. About 5-10% of latent tuberculosis infection without HIV will progress to developed active tuberculosis in their lifetimes. This study was conducted to determine the magnitude of Latent TB among the adult population at a teaching and referral Hospital in Ethiopia.Methods:
This study was conducted at the Chest clinic of Tikur Anbessa Specialized Hospital during 2010-2013.The study was a cross-sectional study conducted among healthy adults after informed consent was obtained from each individual. Tuberculin skin test and Interferon Gamma whole blood assay (Quantiferon-Tuberculosis-Gold) was performed using Enzyme linked Immuno-sorbent Assay. Average CD4, CD8, CD3 and CD4CD8 ratio was determined for all study participants.Results:
From a total of 70 healthy adults tested for latent tuberculosis infection using Quantiferon Gold,45(64%) tested positive and 25 (36%) were negative for latent tuberculosis infection. From the sixty six healthy individuals who were tested using tuberculin skin test for latent tuberculosis infection, 42 (62%) individuals were Tuberculin skin test positive and 25 (38%) individuals were Tuberculin skin test negative. Average CD4, CD8, CD3 and CD4CD8 ratio was 748, 598, 1401 and 1.4, respectively.Conclusions:
The magnitude of latent tuberculosis infection was high in this study, which reflects existing high prevalence of tuberculosis.Tuberculin skin test and Quantiferon-Tuberculosis-Goldassay show similar efficacy for the diagnosis of latent tuberculosis infection in healthy Ethiopian adults. The absolute CD4 T-cell counts of healthy HIV-negative Ethiopian's are considerably lower than other countries
Full text:
1
Index:
AIM
Main subject:
Prevalence
/
Cross-Sectional Studies
/
Adult
/
Ethiopia
/
Latent Tuberculosis
/
Mycobacterium tuberculosis
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Country/Region as subject:
Africa
Language:
Fr
Journal:
Ethiop. med. j. (Online)
Year:
2016
Type:
Article