Antitumour Activity of Methanolic Extract of Plumeria alba L. Leaves against Dalton Lymphoma Ascites in Mice
International Journal of Health Research
; 1(2): 79-85, 2008.
Article
in En
| AIM
| ID: biblio-1263029
Responsible library:
CG1.1
ABSTRACT
Purpose:
To evaluate Plumeria alba leaves for antitumor activity against Ehrlich ascites carcinoma (EAC) and Dalton lymphoma ascites (DLA) bearing Swiss albino mice.Method:
The antitumour activity of the methanolic extract of Plumeria alba leaves (MPA) was evaluated against EAC and DLA using in-vitro cytotoxic and mean survival time; a decrease in the tumour volume and viable cell count in the DLA tumour hosts. The animal was observed for improvement in the haematological parameters (e.g.; heamoglobin content; red and white blood cells count; and differential cell count) following MPA treatment of the tumour bearing mice.Results:
MPA was found to be cytotoxic in the in-vitro model. Intraperitoneal administration of MPA increased the survival time; dead cell count haematological parameters and solid tumour mass was also significantly reduced.Conclusion:
MPA possesses significant antitumour activity
Full text:
1
Index:
AIM
Main subject:
Ascites
/
Apocynaceae
/
Methanol
/
Mice
/
Antineoplastic Agents
Language:
En
Journal:
International Journal of Health Research
Year:
2008
Type:
Article