Human Immunodeficiency Virus Type-1 and cytokines in Colostrum from HIV-infected Mothers in Burkina Faso
J. infect. dev. ctries
;
1(1): 25-29, 2007.
Article
in English
| AIM
| ID: biblio-1263541
ABSTRACT
Background:
The colostrum of HIV-infected mothers contains a high number of HIV copies and is considered highly infectious. Furthermore it contains large numbers of macro- phage and other mononuclear cells that are known to incorporate virus. While prevention protocols in Western countries suggest the interruption of breast feeding; at least for the first few months of life; this practice is not advisable in developing countries.Methodology:
The aim of this study was to determine the HIV load and the concentrations of IL-18; IL-16; IL-12; TGF-beta1 and TGF-beta2 in the colostrum of HIV-infected mothers living in Burkina Faso. The women all received nevirapine prophylaxis during labour.Results:
The viral load in the colostrum decreased rapidly during the first three days following delivery; while the concentration of IL-18 and IL-16 increased in the same period. IL-12; TGF-beta1 and TGF-beta2 did not show significant variations in the first three days after delivery.Conclusions:
Since the viral load decreases in the colostrum of nevirapine-treated expectant mothers; our data suggest single dose nevirapine combined with interruption of early feeding may have potential as a way to reduce the risk of MTCT
Full text:
Available
Index:
AIM (Africa)
Main subject:
Cytokines
/
HIV
/
Colostrum
/
Nevirapine
/
Mothers
Type of study:
Practice guideline
Language:
English
Journal:
J. infect. dev. ctries
Year:
2007
Type:
Article
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