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Changes in remnant-like particle cholesterol level during treatment of hypertension with amlodipine and cilnidipine
Ahaneku, J. E; Sakata, K; Urano, T; Nagai, N; Ihara, H; Pawlak, R; Takada, Y; Takada, A.
  • Ahaneku, J. E; s.af
  • Sakata, K; s.af
  • Urano, T; s.af
  • Nagai, N; s.af
  • Ihara, H; s.af
  • Pawlak, R; s.af
  • Takada, Y; s.af
  • Takada, A; s.af
Article in English | AIM | ID: biblio-1264325
ABSTRACT
This study was designed to determine the effect of antihypertensive agents (calcium channel blockers) on the levels of remnant-like particle (RLP) cholesterol; a major risk factor for coronary heart disease, during treatment of hypertension. Thirty six hypertensive patients of both sexes were selected into this study. Twenty-five of them were treated with amlodipine while eleven patients were treated with cilnidipine all for 3 months. At the beginning and after 3 months of treatment, serum RLP-cholesterol levels were measured in the two treatment groups. RLP-cholesterol level was significantly reduced after clinidipine treatment while the reduction in RLP-cholesterol level after amlodipine treatment was not statistically significant. Our findings show that calcium channel blockers may lower the risk of myocardial infarction, coronary atherosclerosis and/or coronary thrombus formation through reduction in RLP-cholesterol levels during antihypertensive pharmacotherapy
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Index: AIM (Africa) Type of study: Risk factors Language: English Journal: Journal of Biomedical Investigation Year: 2004 Type: Article

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Index: AIM (Africa) Type of study: Risk factors Language: English Journal: Journal of Biomedical Investigation Year: 2004 Type: Article