An in vitro evaluation of antimicrobial interaction between glycine and some penicillins using the decimal assay for additivity (daa) method
Journal of Pharmacetuical and Allied Sciences
;
3(1): 289-293, 2005.
Article
in English
| AIM
| ID: biblio-1264461
ABSTRACT
The decimal assay for additivity (DAA) method was used to evaluate the in vitro interaction of glycine (Gly) with penicillin G (Pen G); cloxacillin (Clox) and ampicillin (Amp) against a clinical isolate of Staphylococcus aureus. In the interaction between Pen G/glycine with biological equivalent factor (BEF) 5 mg/62 mg; the decimal combination of 4 parts Pen G and 6 parts glycine showed amtagpmos; wjo;e ptjers sjpwed addotive effect In the interaction between Clox/glycine with BEF 1.26 og/62.5 mg ony 73 combination gave a synergistic effect. Others showed antagonism. In Amp/glycine combination with BEF; 1.74 og/62.5 mg; the decimal combinations of 46 gave additive effect; 91 gave synergistic effect while 73 combinaiton gave indifferent effect
Full text:
Available
Index:
AIM (Africa)
Main subject:
Penicillins
/
Research
/
Glycine
Language:
English
Journal:
Journal of Pharmacetuical and Allied Sciences
Year:
2005
Type:
Article
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