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Relationship between hormonal profile and therapeutic testicular biopsy/ tese findings in azoospermic men
Ofoha, Chimaobi G; Dakum, Nuhu K.
  • Ofoha, Chimaobi G; s.af
  • Dakum, Nuhu K; s.af
Orient Journal of Medicine ; 32(1-2): 39-45, 2020. ilus
Article in English | AIM | ID: biblio-1268295
ABSTRACT
Background. Meta-analyses of the implementation of a surgical safety checklist (SSC) in observational studies have shown a significant decrease in mortality and surgical complications.Objective. To determine the efficacy of the SSC using data from randomised controlled trials (RCTs).Methods. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered with PROSPERO (CRD42015017546). A comprehensive search of six databases was conducted using the OvidSP search engine.Results. Four hundred and sixty-four citations revealed three eligible trials conducted in tertiary hospitals and a community hospital, with a total of 6 060 patients. All trials had allocation concealment bias and a lack of blinding of participants and personnel. A single trial that contributed 5 295 of the 6 060 patients to the meta-analysis had no detection, attrition or reporting biases. The SSC was associated with significantly decreased mortality (risk ratio (RR) 0.59, 95% confidence interval (CI) 0.42 - 0.85; p=0.0004; I2=0%) and surgical complications (RR 0.64, 95% CI 0.57 - 0.71; p<0.00001; I2=0%). The efficacy of the SSC on specific surgical complications was as follows respiratory complications RR 0.59, 95% CI 0.21 - 1.70; p=0.33, cardiac complications RR 0.74, 95% CI 0.28 - 1.95; p=0.54, infectious complications RR 0.61, 95% CI 0.29 - 1.27; p=0.18, and perioperative bleeding RR 0.36, 95% CI 0.23 - 0.56; p<0.00001.Conclusions. There is sufficient RCT evidence to suggest that SSCs decrease hospital mortality and surgical outcomes in tertiary and community hospitals. However, randomised evidence of the efficacy of the SSC at rural hospital level is absent
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Full text: Available Index: AIM (Africa) Main subject: Biopsy / Azoospermia / Infertility / Nigeria Type of study: Controlled clinical trial / Observational study / Systematic reviews Country/Region as subject: Africa Language: English Journal: Orient Journal of Medicine Year: 2020 Type: Article

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Full text: Available Index: AIM (Africa) Main subject: Biopsy / Azoospermia / Infertility / Nigeria Type of study: Controlled clinical trial / Observational study / Systematic reviews Country/Region as subject: Africa Language: English Journal: Orient Journal of Medicine Year: 2020 Type: Article