Anti-Platelet Drugs; Pharmacogenomics and Stent Thrombosis: What's New?
SA Heart Journal
;
7(3): 150-153, 2010.
Article
in English
| AIM
| ID: biblio-1271321
ABSTRACT
Stent thrombosis is a catastrophic complication of percutaneous coronary intervention (PCI) and is associated with a mortality of 25 to 40. The perception that stent thrombosis is very low in all patients has resulted in a lack of adherence to professional guidelines. New data to identify patients at increased risk for stent thrombosis are emerging. Clopidogrel is a prodrug and the activation of clopidogrel is dependent on CY2C19. Numerous alleles of CYP2C19 exist. The allele CYP2CP*2 has been associated with a marked decrease in platelet responsiveness to clopidogrel. Heterozygote carriers of the CYP2C19*2 have a 2.7 fold increased risk and homozygotes a 4.8 fold increased risk of stent thrombosis. Prospective randomised clinical trials will be necessary to determine the efficacy of CYP2C19 genotypedirected therapy in evidence-based clinical decision making. Point-of-care platelet-function tests are becoming recent available and some centres are now performing such tests on their PCI patients. The most AHA/ACC /SCAI guidelines recommend testing for clopidogrel responsiveness in patients at high risk of sub acute stent thrombosis and recommend increasing the dose of clopidogrel in nonresponders
Full text:
Available
Index:
AIM (Africa)
Main subject:
Pharmacogenetics
/
Coronary Thrombosis
/
Platelet Aggregation Inhibitors
/
Risk Factors
Type of study:
Controlled clinical trial
/
Etiology study
/
Practice guideline
/
Prognostic study
/
Risk factors
Language:
English
Journal:
SA Heart Journal
Year:
2010
Type:
Article
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