Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced Hepatotoxicity
Trop. j. pharm. res. (Online)
;
5(1): 539-544, 2006.
Article
in English
| AIM
| ID: biblio-1273079
ABSTRACT
A study on the protective effect of Moringa oleifera leaf extract in acute alcohol-induced hepatotoxicity in rats was evaluated. Rats fed alcohol only produced significant increase in the levels of enzyme markers of tissues damage (ALT; AST and ALP); lipid peroxidation (TBARS) and decreased serum vitamin C levels compared to normal control rats. Pretreatment with 100 and 200mg/kg body weight of extract significantly decreased the levels of enzyme markers; lipid peroxidation and markedly increased serum vitamin C level in a dose-dependent manner. Post-treatment with 200mg/kg body weight of extract significantly enhanced the recovery of animals from hepatic damage compared to untreated control. Lipid peroxidation and depletion of vitamin C due to oxidative stress could be the possible mechanisms of alcohol induced toxicity and the protective effect of the extract could be as a result of its ability to inhibit lipid peroxidation and prevent the depletion of vitamins C
Full text:
Available
Index:
AIM (Africa)
Main subject:
Ascorbic Acid
/
Lipid Peroxidation
/
Moringa oleifera
Language:
English
Journal:
Trop. j. pharm. res. (Online)
Year:
2006
Type:
Article
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