Microstructural observations on nissl substances in the cerebellar cortex of adult wistar rats following quinine administration
Trop. j. pharm. res. (Online)
;
8(2): 105-109, 2009. figures
Article
in English
| AIM
| ID: biblio-1273111
ABSTRACT
Purpose:
This study assessed some microstructural effects of quinine; commonly used in malaria chemotherapy; especially in chloroquine-resistant and cerebral malaria; on the Nissl substance in the cerebellar cortex of adult Wistar rats using microanatomical studies.Methods:
Twenty seven adult male Wistar rats; weighing between 150g and 190g; were randomly separated into groups A; B and C (n=9). The rats in group A served as the control and received intramuscular injection of physiological saline. Group B rats were injected intramuscularly with liquid quinine; 16mg/kg body weight as a start dose; followed by 8mg/kg body weight 8 hourly for seven days. Group C rats received the same treatment as group B but were subjected to a withdrawal period of one week. Groups A and B rats were sacrificed at the end of the treatment while group C rats were sacrificed at the end of one week. The cerebellum of each rat was removed and fixed in 10formol saline for histological analysis.Results:
The findings showed that the Nissl substances in the cerebellar cortex in control rats stained more intensely and distinctly compared with the less intense stain and degenerated Nissl substances in the treated rats.Conclusion:
The observed degenerative changes in the Nissl substances in the cerebellar cortex of the treated rats may affect the synthesis of proteins in correlation with neuronal functions
Full text:
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Index:
AIM (Africa)
Main subject:
Quinine
/
Cerebellar Cortex
/
Malaria
/
Nigeria
/
Nissl Bodies
Limits:
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
Trop. j. pharm. res. (Online)
Year:
2009
Type:
Article
Institution/Affiliation country:
Department of Physiology, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology/NG
/
Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences/NG
/
Department of Anatomy, Faculty of Basic Medical Sciences/NG
/
Department of Anatomy, Faculty of Basic Medical Sciences,/NG
/
Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University/NG
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