Physicochemical Analysis of the Aqueous Extracts of Six Nigerian Medicinal Plants
Trop. j. pharm. res. (Online)
;
9(2): 119-125, 2010.
Article
in English
| AIM
| ID: biblio-1273132
ABSTRACT
Purpose:
Extracts of Picralima nitida seeds; Detarium microcarpum stem bark; Aframomum melagueta seeds; Terminalia catappa leaves; Acacia nilotica pods; and Morinda lucida stem bark; are under consideration for development into suitable dosage forms for treating diabetes mellitus; sickle cell anemia and malaria. This study aimed at evaluating the extracts for features that would influence decisions on them in the course of the project.Methods:
Physicochemical determinations; including proximate analysis; were done by sensory examination; and gravimetric and electrochemical techniques. Thin layer chromatography was carried out with normal silica plates using various solvent systems. Metallic content analyses were carried out by atomic absorption spectroscopy.Results:
The extracts were dry but hygroscopic; with a loss on drying range of 0.26 - 12.00w/w. The pH of the 5 - 10solutions ranged 5 - 7. No harsh sensory effects; such as lacrimation; were detected in any of the extracts. Total ash ranged from 3.79 - 20.68w/w; while acid insoluble ash values were below detection. The extracts yielded reproducible chromatograms on normal silica plates developed with various solvent systems. Copper; present at 0.16 - 0.58 mg/100g; was the lowest occurring microelement while calcium content was highest; at 41 - 216 mg/100g. The level of lead; a heavy metal; was 0.05 - 0.22 mg/100g.Conclusion:
The results confirm that the extracts require no special handling; possess characteristics that would allow their possible development into solid dosage forms; and that their lead contents complied with official limits
Full text:
Available
Index:
AIM (Africa)
Main subject:
Plants
/
Plant Extracts
/
Terminalia
/
Zingiberaceae
/
Morinda
/
Acacia
Type of study:
Prognostic study
Language:
English
Journal:
Trop. j. pharm. res. (Online)
Year:
2010
Type:
Article
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