Kaposi's Sarcoma in AIDS: High incidence of Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus in tumor lesions and peripheral blood mononuclear cells from patients with Kaposi's sarcoma in Uganda
Uganda health inf. dig
; 1(3): 16-1997.
Article
in En
| AIM
| ID: biblio-1273271
Responsible library:
CG1.1
ABSTRACT
With the advent of AIDS; Kaposi's sarcom (KS) has become one of the leading malignancies in sub-Saharan Africa. Recently; DNA sequences from a new human herpesvirus called KS-associated herpesvirus (KSHV) or human herpesvirus type 8 have been found in KS tumor lesions as revealed by polymerase chain reaction and Southern hybridization. In contrast; only 31(11/36) of the normal skin biopsies from the same patient population were positive. The frequency of KSHV DNA detection in peripheral blood mononuclear cells (PBMC) of KS patients was also high (84; 31/37). Similar analyses revealed the presence of cytomegalovirus (21in KS lesions) to be discordant with KS PBMC (70; 26/37) were; however; positive for Epstein-Barr virus sequences. In addition; KSHV DNA was not found in the PBMC of Ugandans without KS. (Source J. Infect. Dis. 1997 April; 175(4)947-50)
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Index:
AIM
Main subject:
Sarcoma
/
Humans
/
Herpesviridae Infections
/
Neoplasms
Type of study:
Incidence_studies
/
Risk_factors_studies
Language:
En
Journal:
Uganda health inf. dig
Year:
1997
Type:
Article