Is intravenous long-acting opioid (morphine) associated with more postoperative hypoxemia than short-acting opioid (fentanyl) after non-cardiac surgery?
Zagazig univ. med. j
;
25(3): 308-316, 2019.
Article
in English
| AIM
| ID: biblio-1273852
ABSTRACT
Background:
morphine is a potent analgesic in decreasing postoperative pain; however its use is accompanied by many complications especially respiratory one. On the other side, fentanyl titration may cause less postoperative respiratory complications.Objective:
To compare between intravenous long-acting opioid (Morphine), and short-acting opioid (Fentanyl) regarding postoperative hypoxemia after non-cardiac surgery. Patients andmethods:
A prospective randomized clinical study done on 52 patients, they were divided equally into two groups Group M (Morphine) received (0.1mg/kg), and Group F (Fentanyl) received (1ug/kg) on induction, and supplemented by effective rescue analgesia. When postoperative VAS score â¥4 , patients in Group M received 5mg morphine as bolus ,and re-assess pain every 5 min to give another bolus ( the total allowed dose was 15mg/3-4h).For Group F 50ug fentanyl was given as a bolus ,and could be repeated (total allowed dose was 100 ug/1-2h.). Result(s) There were no significant difference between two groups as regard respiratory rate (RR) nor peripheral O2 saturation (SPO2) (P value0.05).Conclusion:
Intravenous morphine as effective rescue analgesic is not associated with more postoperative hypoxemia, or respiratory depression than fentanyl
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Index:
AIM (Africa)
Main subject:
Postoperative Period
/
Surgical Procedures, Operative
/
Fentanyl
/
Analgesics, Opioid
/
Hypoxia
Type of study:
Controlled clinical trial
/
Risk factors
Language:
English
Journal:
Zagazig univ. med. j
Year:
2019
Type:
Article
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