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Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil
Rodrigues, D K B; Bonfietti, L X; Garcia, R A; Araujo, M R; Rodrigues, J S; Gimenes, V M F; Melhem, M S C.
  • Rodrigues, D K B; s.af
  • Bonfietti, L X; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde. São Paulo. BR
  • Garcia, R A; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde. São Paulo. BR
  • Araujo, M R; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde. São Paulo. BR
  • Rodrigues, J S; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde. São Paulo. BR
  • Gimenes, V M F; Instituto de Medicina Tropical, Universidade de São Paulo. Laboratório de Micologia Médica-LIM 53. São Paulo. BR
  • Melhem, M S C; Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde. São Paulo. BR
Braz. j. med. biol. res ; 54(9): e10928, 2021. graf
Article in English | LILACS | ID: biblio-1278587
Responsible library: BR1.1
ABSTRACT
This study aimed to evaluate the frequency of cryptic Candida species from candidemia cases in 22 public hospitals in São Paulo State, Brazil, and their antifungal susceptibility profiles. During 2017 and 2018, 144 isolates were molecularly identified as 14 species; C. parapsilosis (32.6%), C. albicans (27.7%), C. tropicalis (14.6%), C. glabrata (9.7%), C. krusei (2.8%), C. orthopsilosis (2.8%), C. haemulonii var. vulnera (2.1%), C. haemulonii (1.4%), C. metapsilosis (1.4%), C. dubliniensis (1.4%), C. guilliermondii (1.4%), C. duobushaemulonii (0.7%), C. kefyr (0.7%), and C. pelliculosa (0.7%). Poor susceptibility to fluconazole was identified in 6.4% of C. parapsilosis isolates (0.12 to >64 µg/mL), 50% of C. guilliermondii (64 µg/mL), 66.6% of C. haemulonii var. vulnera (16-32 µg/mL), and C. duobushaemulonii strain (MIC 64 µg/mL). Our results corroborated the emergence of C. glabrata in Brazilian cases of candidemia as previously reported. Importantly, we observed a large proportion of non-wild type C. glabrata isolates to voriconazole (28.6%; <0.015 to 4 µg/mL) all of which were also resistant to fluconazole (28.6%). Of note, C. haemulonii, a multidrug resistant species, has emerged in the Southeast region of Brazil. Our findings suggested a possible epidemiologic change in the region with an increase in fluconazole-resistant species causing candidemia. We stress the relevance of routine accurate identification to properly manage therapy and monitor epidemiologic trends.
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Full text: Available Index: LILACS (Americas) Main subject: Candida / Antifungal Agents Type of study: Prognostic study Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Medicina Tropical, Universidade de São Paulo/BR / Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde/BR

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Full text: Available Index: LILACS (Americas) Main subject: Candida / Antifungal Agents Type of study: Prognostic study Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto de Medicina Tropical, Universidade de São Paulo/BR / Núcleo de Micologia do Instituto Adolfo Lutz, Secretaria de Saúde/BR