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Meta-analysis of the relationship between interleukin-6 levels and the prognosis and severity of acute coronary syndrome
Yang, Chongzhe; Deng, Zhiyong; Li, Jie; Ren, Zhilei; Liu, Feng.
  • Yang, Chongzhe; South China University of Technology. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First Peoples Hospital, School of Medicine. Guangzhou. CN
  • Deng, Zhiyong; South China University of Technology. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First Peoples Hospital, School of Medicine. Guangzhou. CN
  • Li, Jie; South China University of Technology. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First Peoples Hospital, School of Medicine. Guangzhou. CN
  • Ren, Zhilei; South China University of Technology. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First Peoples Hospital, School of Medicine. Guangzhou. CN
  • Liu, Feng; South China University of Technology. Department of Geriatrics, National Key Clinic Specialty, Guangzhou First Peoples Hospital, School of Medicine. Guangzhou. CN
Clinics ; 76: e2690, 2021. tab, graf
Article in English | LILACS | ID: biblio-1278911
ABSTRACT
This study aimed to explore the relationship between plasma interleukin 6 (IL-6) levels, adverse cardiovascular events, and the severity of acute coronary syndrome (ACS). A literature review was performed of studies regarding IL-6 and ACS extracted from databases including EMBASE, Cqvip, MEDLINE, Web of Knowledge, PubMed, Cochrane Library, China National Knowledge Infrastructure, and Wanfang data. The Newcastle-Ottawa scale (NOS) was used to evaluate the quality of the literature. The literature was screened, its quality was evaluated, and relevant data were extracted for performing meta-analysis using RevMan software (version 5.3). A total of 524 studies were included in the initial survey. After several rounds of screening and analysis, six studies met the inclusion criteria and underwent meta-analysis using a fixed-effect model. Patients were divided into non-severe and severe groups based on the concentration of high-sensitivity C-reactive protein. Meta-analysis of the relationship between IL-6 and the severity of ACS showed that the plasma IL-6 level of patients in the severe group was significantly higher than that of patients in the non-severe group (p<0.00001). Additionally, patients with experience of major adverse cardiovascular events had significantly higher plasma IL-6 levels than did patients without experience of such events (p<0.00001). In summary, patients with ACS and high IL-6 levels tended to be in a critical condition, with a higher risk of adverse cardiovascular events and worse prognosis. Thus, IL-6 levels could indicate whether patients with ACS may have adverse cardiovascular events and determine the severity of ACS.
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Full text: Available Index: LILACS (Americas) Main subject: Interleukin-6 / Acute Coronary Syndrome Type of study: Prognostic study / Systematic reviews Limits: Humans Country/Region as subject: Asia Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: South China University of Technology/CN

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Full text: Available Index: LILACS (Americas) Main subject: Interleukin-6 / Acute Coronary Syndrome Type of study: Prognostic study / Systematic reviews Limits: Humans Country/Region as subject: Asia Language: English Journal: Clinics Journal subject: Medicine Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: South China University of Technology/CN