Análise das alterações endometriais nas histeroscopias de pacientes em tratamento de câncer de mama com bloqueadores hormonais / Analysis of endometrial changes in the histeroscopies of patients treating breast cancer with hormonal blockers
Rev. méd. Paraná
;
79(1): 46-51, 2021.
Article
in Portuguese
| LILACS
| ID: biblio-1282398
RESUMO
Objetivo:
analisar lesões endometriais de pacientes com câncer de mama em tratamento com Tamoxifeno® presentes nas histeroscopias e relacioná-las com a dose de medicamento utilizada, tempo de terapêutica, presença de lesões endometriais prévias e estado de pré ou pós menopausa.Método:
estudo retrospectivo, transversal e analítico. Dados analisados pelo teste qui quadrado, p<0,05.Resultados:
dentre as 75 histeroscopias analisadas, 12 eram normais (16%) e 63 apresentaram alteração endometrial (84%). Dentre os achados das histeroscopias, 49 foram pólipos endometriais (67.12%), 7 foram pólipos endocervicais (9.58%), 11 foram hiperplasia simples sem atipias (15.06%), 1 foi hiperplasia complexa sem atipias (1.36%), 1 foi hiperplasia complexa com atipias (1.36%), 2 foram leiomiomas (2.73%) e 2 foram adenocarcinoma endometrioide (2.73%).Conclusão:
O Tamoxifeno® predispõe o aparecimento de lesões endometriais, que podem ser malignas. Nesse estudo, a incidência dessas lesões foi expressivamente maior do que os valores encontrados na literaturaABSTRACT
Objective:
To analyze the endometrial lesions in hysteroscopies of patients with breast cancer undergoing treatment with Tamoxifeno® and to relate them to the dose of medication used, time of therapy, presence of previous endometrial lesions and pre or postmenopausal status.Method:
retrospective, cross-sectional and analytical study. Data were statistically analyzed using the chi-square test, p <0.05.Results:
Among the 75 hysteroscopies analyzed, 12 were normal (16%) and 63 presented endometrial alteration (84%). Among the hysteroscopic findings, 49 were endometrial polyps (67.12%), 7 were endocervical polyps (9.58%), 11 were simple hyperplasia without atypias (15.06%), 1 was complex hyperplasia without atypias (1.36%), 1 was complex hyperplasia with atypia (1.36%), 2 were leiomyomas (2.73%) and 2 were endometrioid adenocarcinoma (2.73%).Conclusion:
Tamoxifen predisposes the appearance of endometrial lesions, which may be malignant. In this study, the incidence of these lesions was significantly higher than the values found in the literature
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tamoxifen
/
Therapeutics
/
Breast Neoplasms
/
Hysteroscopy
/
Carcinoma, Endometrioid
Type of study:
Evaluation studies
/
Observational study
Limits:
Female
/
Humans
Language:
Portuguese
Journal:
Rev. méd. Paraná
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade Evangélica Mackenzie do Paraná/BR
Similar
MEDLINE
...
LILACS
LIS