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Comparison of two different biomaterials in the bone regeneration (15, 30 and 60 days) of critical defects in rats
Postgraduate Program in Evolutionary Genetics and Molecular BiologyBrassolatti, Patricia; Bossini, Paulo Sérgio; Andrade, Ana Laura Martins de; Metabolic Endocrine Research LaboratoryLuna, Genoveva Lourdes Flores; Silva, Juliana Virginio da; Almeida-Lopes, Luciana; Napolitano, Marcos Aurélio; Avó, Lucimar Retto da Silva de; Leal, Ângela Merice de Oliveira; Anibal, Fernanda de Freitas.
  • Postgraduate Program in Evolutionary Genetics and Molecular BiologyBrassolatti, Patricia; Universidade Federal de São Carlos. Department of Morphology and Pathology. Postgraduate Program in Evolutionary Genetics and Molecular BiologyBrassolatti, Patricia. Sao Carlos. BR
  • Bossini, Paulo Sérgio; NUPEN - Research and Education Center in Health Science and DMC Equipment Import and Export-Co. Sao Carlos. BR
  • Andrade, Ana Laura Martins de; Universidade Federal de São Carlos. Department of Physiotherapy. Sao Carlos. BR
  • Metabolic Endocrine Research LaboratoryLuna, Genoveva Lourdes Flores; Universidade Federal University de São Carlos. Department of Medicine. Metabolic Endocrine Research LaboratoryLuna, Genoveva Lourdes Flores. Sao Carlos. BR
  • Silva, Juliana Virginio da; Universidade de São Paulo. Institute of Physics of Sao Carlos. Sao Carlos. BR
  • Almeida-Lopes, Luciana; NUPEN - Research and Education Center in Health Science and DMC Equipment Import and Export-Co. Sao Carlos. BR
  • Napolitano, Marcos Aurélio; DMC Equipment Import and Export-Co. Sao Carlos. BR
  • Avó, Lucimar Retto da Silva de; Universidade Federal de São Carlos. Department of Medicine. Sao Carlos. BR
  • Leal, Ângela Merice de Oliveira; Universidade Federal de São Carlos. Department of Medicine. Sao Carlos. BR
  • Anibal, Fernanda de Freitas; Universidade Federal de São Carlos. Department of Morphology and Pathology. Sao Carlos. BR
Acta cir. bras ; 36(6): e360605, 2021. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1284912
ABSTRACT
ABSTRACT Purpose To evaluate and compare two types of different scaffolds in critical bone defects in rats. Methods Seventy male Wistar rats (280 ± 20 grams) divided into three groups control group (CG), untreated animals; biomaterial group 1 (BG1), animals that received the scaffold implanted hydroxyapatite (HA)/poly(lactic-co-glycolic) acid (PLGA); and biomaterial group 2 (BG2), animals that received the scaffolds HA/PLGA/Bleed. The critical bone defect was induced in the medial region of the skull calotte with the aid of an 8-mm-diameter trephine drill. The biomaterial was implanted in the form of 1.5 mm thick scaffolds, and samples were collected after 15, 30 and 60 days. Non-parametric Mann-Whitney test was used, with the significance level of 5% (p ≤ 0.05). Results Histology revealed morphological and structural differences of the neoformed tissue between the experimental groups. Collagen-1 (Col-1) findings are consistent with the histological ones, in which BG2 presented the highest amount of fibers in its tissue matrix in all evaluated periods. In contrast, the results of receptor activator of nuclear factor kappa-Β ligand (Rank-L) immunoexpression were higher in BG2 in the periods of 30 and 60 days, indicating an increase of the degradation of the biomaterial and the remodeling activity of the bone. Conclusions The properties of the HA/PLGA/Bleed scaffold were superior when compared to the scaffold composed only by HA/PLGA.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Biocompatible Materials / Tissue Scaffolds Limits: Animals Language: English Journal: Acta cir. bras Year: 2021 Type: Article Institution/Affiliation country: NUPEN - Research and Education Center in Health Science and DMC Equipment Import and Export-Co/BR / Universidade Federal University de São Carlos/BR / Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Biocompatible Materials / Tissue Scaffolds Limits: Animals Language: English Journal: Acta cir. bras Year: 2021 Type: Article Institution/Affiliation country: NUPEN - Research and Education Center in Health Science and DMC Equipment Import and Export-Co/BR / Universidade Federal University de São Carlos/BR / Universidade Federal de São Carlos/BR / Universidade de São Paulo/BR