Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
Arch. endocrinol. metab. (Online)
;
65(3): 305-314, May-June 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1285150
ABSTRACT
ABSTRACT Objective:
To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials andmethods:
This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (body weight, BMI, waist circumference and fat mass percentage), metabolic markers (glucose, insulin, HOMAIR, leptin, total cholesterol, LDLc, HDLc, triglycerides, ALT, GGT and hsCRP) and blood pressure was analyzed by linear regression.Results:
The minor allele (T) of the SLC16A11 gene (rs75493593) has a frequency of 29.7% among Chileans. Risk genotypes (GT and TT) were associated with a significant 1.49 mU/l increase in plasmatic insulin for each copy of the minor allele (95% CI 0.12, 2.87, p < 0.05). This association remained significant after adjusting for socio-demographic variables, physical activity and smoking (1.36 mU/l, 95% CI 0.16, 2.58 p < 0.05), but was lost when BMI was included as a confounding factor. Higher BMI was also significantly associated with polymorphic genotypes in SLC16A11, independent of socio-demographic variables.Conclusion:
The minor allele of the SLC16A11 gene (T) is highly prevalent among Chileans and is associated with increased insulin and BMI in nondiabetic individuals. These findings suggest that the genetic variant in SLC16A11 is not only associated with type 2 diabetes as previously shown in Mexicans, but is also related to early metabolic alterations in healthy subjects that may lead to type 2 diabetes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Body Mass Index
/
Monocarboxylic Acid Transporters
/
Insulin
Type of study:
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adult
/
Humans
Country/Region as subject:
South America
/
Chile
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2021
Type:
Article
Affiliation country:
Chile
/
United kingdom
Institution/Affiliation country:
Universidad Austral de Chile/CL
/
Universidad Católica de la Santísima Concepción/CL
/
Universidad Santo Tomas/CL
/
Universidad de Chile/CL
/
Universidad de Concepción/CL
/
University of Glasgow/GB
Similar
MEDLINE
...
LILACS
LIS