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Ultrasonographic differentiation and Ultrasound-based management of partially cystic thyroid nodules
Liu, Yanjun; Zhao, Yanru; Fu, Jiao; Liu, Shu.
  • Liu, Yanjun; the First Affiliated Hospital of Xian Jiaotong University. Department of Endocrinology. Xian. CN
  • Zhao, Yanru; the First Affiliated Hospital of Xian Jiaotong University. Department of Endocrinology. Xian. CN
  • Fu, Jiao; the First Affiliated Hospital of Xian Jiaotong University. Department of Endocrinology. Xian. CN
  • Liu, Shu; the First Affiliated Hospital of Xian Jiaotong University. Department of Endocrinology. Xian. CN
Arch. endocrinol. metab. (Online) ; 65(3): 336-341, May-June 2021. tab
Article in English | LILACS | ID: biblio-1285154
ABSTRACT
ABSTRACT

Objective:

To determine sonographic features of malignancy in partially cystic thyroid nodules and assess the diagnostic efficacy of these features for differentiating between benign and malignant lesions in the nodules with indeterminate cytology. Subjects and

methods:

From January 2016 to December 2017, a total of 91 patients with 94 partially cystic thyroid nodules who had undergone ultrasound-guided fine-needle aspiration biopsy and thyroid surgery in our hospital were included in this study. The sonographic features of the thyroid nodules were analyzed to identify the predictive features of malignancy and assess the diagnostic efficacy of these features.

Results:

The features of hypoechogenicity, microcalcification, composition, and an eccentric solid component with an acute angle had statistically significant associations with malignant nodule (p<005) by univariable analysis. Binary logistic regression analysis showed that microcalcification and hypoechogenicity were significantly associated with malignancy. Using the combination of microcalcification, hypoechogenicity, and a solid component comprising of greater than or equal to 50% of the total volume, the diagnostic sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 97.6%, 32.7%, 53.9%, and 94.4%, respectively. In these nodules with indeterminate cytology, this combination also exhibited a high sensitivity of 92.3% and an NPV of 83.3%.

Conclusion:

This study demonstrated that microcalcification and hypoechogenicity were independently associated with malignancy in partially cystic thyroid nodules. The combination of microcalcification, hypoechogenicity, and a solid portion that is greater than or equal to 50% of the total volume will help guide clinical decisions in mixed cystic solid nodules.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyroid Nodule Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: the First Affiliated Hospital of Xian Jiaotong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyroid Nodule Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: the First Affiliated Hospital of Xian Jiaotong University/CN