Squamous cell carcinoma with sarcomatous transformation of the penis
Autops. Case Rep
;
11: e2021303, 2021. graf
Article
in English
| LILACS
| ID: biblio-1285401
ABSTRACT
Malignant tumors of the penis are rare, most of them being squamous cell carcinomas (SCCs). We report the case of a 75-year-old man with a large penile mass submitted to partial penectomy. The specimen showed an exophytic mass involving the glans, coronal sulcus, and prepuce. Microscopic examination showed a carcinoma with two distinct areas a mixed SCC and a sarcomatoid carcinoma. The SCC component had areas of verrucous carcinoma and areas of classical invasive SCC. The tumor cells expressed p63 with the absence of p16 expression. Vimentin and p53 were positive in the sarcomatous component. The morphology and immunohistochemistry were compatible with mixed SCC (verrucous hybrid-sarcomatoid carcinoma). Additionally, the tumor cells also expressed 3 different clones of PDL1 (22C3, SP263, and SP142). Two months later, the patient presented local recurrence with multiple lymph nodes and lung metastases, dying 7 weeks later. Mixed tumors represent diagnostic challenges. The correct identification of adverse prognostic factors can be the first step to implement the treatment with a higher probability of success.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Penile Neoplasms
/
Carcinoma, Squamous Cell
/
Carcinoma, Verrucous
Type of study:
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2021
Type:
Article
Affiliation country:
Portugal
Institution/Affiliation country:
Instituto Português de Oncologia de Lisboa (IPO Lisboa)/PT
/
Instituto Português de Oncologia de Lisboa/PT
/
Unidade Local de Saúde de Matosinhos/PT
/
Universidade do Porto (U. Porto)/PT
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