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Papillary thyroid carcinoma with nodular fasciitis-like stroma: a rare variant
Parkhi, Mayur; Chatterjee, Debajyoti; Bardia, Anand; Kanaval, Anwin Joseph; Sood, Ashwani; Saikia, Uma Nahar; Bansal, Naval.
  • Parkhi, Mayur; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Chatterjee, Debajyoti; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Bardia, Anand; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Kanaval, Anwin Joseph; Post Graduate Institute and Medical Education and Research. Department of Nuclear Medicine. Chandigarh. IN
  • Sood, Ashwani; Post Graduate Institute and Medical Education and Research. Department of Nuclear Medicine. Chandigarh. IN
  • Saikia, Uma Nahar; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Bansal, Naval; Fortis Hospital. Department of Surgery. Mohali. IN
Autops. Case Rep ; 11: e2021320, 2021. tab, graf
Article in English | LILACS | ID: biblio-1285403
ABSTRACT
Papillary thyroid carcinoma with desmoid-type fibromatosis (PTC-DTF) or nodular fasciitis-like stroma (PTC-NFS) is a rare morphological variant of PTC with a favorable prognosis. There is a paucity of molecular data regarding this entity. We present the case of a 20-year-old female who presented with a palpable mass over the anterior aspect of the neck for the past 3-4 months, which was diagnosed as PTC-NFS. Ultrasonogram of the neck revealed a bulky left lobe of thyroid that contained a well-defined heterogenous lesion measuring around 24 × 26 × 36 mm with involvement of the adjacent isthmus. She underwent a total thyroidectomy with central compartment lymph node dissection. Histological examination revealed a biphasic tumor with epithelial and stromal components resembling nodular fasciitis. Two dissected lymph nodes showed metastasis of the epithelial component only. On immunohistochemistry, BRAF mutant protein expression was evident in the epithelial component only, while β-catenin was negative in both the components. The histopathological diagnosis of papillary thyroid carcinoma with nodular fasciitis-like stroma was offered. Sanger sequencing revealed a BRAFV600E (c.1799T>A, Val600Glu) mutation. Post-operatively, no residual tumor was detected on ultrasound and radioiodine scans. The patient was doing well at follow-up of 9 months. PTC-NFS/DTF is a histological variant of PTC with a favorable prognosis. Our index case was associated with the BRAF mutation, which was restricted to the epithelial component. Thorough sampling of the excised specimen is essential in order not to miss the epithelial component, which, in most reported cases (including ours) appears to be small.
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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyroid Cancer, Papillary Type of study: Prognostic study Limits: Adult / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Fortis Hospital/IN / Post Graduate Institute and Medical Education and Research/IN

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Full text: Available Index: LILACS (Americas) Main subject: Thyroid Neoplasms / Thyroid Cancer, Papillary Type of study: Prognostic study Limits: Adult / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: India Institution/Affiliation country: Fortis Hospital/IN / Post Graduate Institute and Medical Education and Research/IN