Palbociclib in breast cancer neoadjuvant setting
Autops. Case Rep
;
11: e2021309, 2021. graf
Article
in English
| LILACS
| ID: biblio-1285407
ABSTRACT
Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer. Their activity in this subset of patients leads to interest in their use in the adjuvant and neoadjuvant settings. This case report presents a real-life case of cyclin-dependent kinase 4/6 inhibitors use in a patient initially considered to have stage IV luminal HER2-negative breast cancer with liver metastasis. The discrepancy of treatment response between the breast tumor and liver node led to a repetition of the liver biopsy, which revealed metastasis of a neuroendocrine tumor of unknown primary. The breast tumor showed a partial response, and the initial therapeutic strategy was then redefined for curative intent. While cyclin-dependent kinase 4/6 inhibitors are not yet approved for clinical practice in the neo / adjuvant treatment of hormone receptor-positive breast cancer, this case report portrays a successful example of its application in a neoadjuvant setting.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Carcinoma
/
Cyclin-Dependent Kinase 4
/
Cyclin-Dependent Kinase 6
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2021
Type:
Article
Affiliation country:
Portugal
Institution/Affiliation country:
Centro Hospitalar de Trás-os-Montes e Alto Douro EPE/PT
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