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Palbociclib in breast cancer neoadjuvant setting
Duarte, Sílvia Alexandra Cabral; Azevedo, Daniela Silva Pádua de; Sarmento, Teresa Tomé Ribeiro Malheiro; Sousa, Marta Verónica Velho.
  • Duarte, Sílvia Alexandra Cabral; Centro Hospitalar de Trás-os-Montes e Alto Douro EPE. Medical Oncology Department. Porto Alegre. PT
  • Azevedo, Daniela Silva Pádua de; Centro Hospitalar de Trás-os-Montes e Alto Douro EPE. Medical Oncology Department. Porto Alegre. PT
  • Sarmento, Teresa Tomé Ribeiro Malheiro; Centro Hospitalar de Trás-os-Montes e Alto Douro EPE. Medical Oncology Department. Porto Alegre. PT
  • Sousa, Marta Verónica Velho; Centro Hospitalar de Trás-os-Montes e Alto Douro EPE. Medical Oncology Department. Porto Alegre. PT
Autops. Case Rep ; 11: e2021309, 2021. graf
Article in English | LILACS | ID: biblio-1285407
ABSTRACT
Cyclin-dependent kinase 4/6 inhibitors represent a major advance in breast cancer treatment, emerging as the standard of care of the initial treatment of hormone receptor-positive and HER2-negative metastatic breast cancer. Their activity in this subset of patients leads to interest in their use in the adjuvant and neoadjuvant settings. This case report presents a real-life case of cyclin-dependent kinase 4/6 inhibitors use in a patient initially considered to have stage IV luminal HER2-negative breast cancer with liver metastasis. The discrepancy of treatment response between the breast tumor and liver node led to a repetition of the liver biopsy, which revealed metastasis of a neuroendocrine tumor of unknown primary. The breast tumor showed a partial response, and the initial therapeutic strategy was then redefined for curative intent. While cyclin-dependent kinase 4/6 inhibitors are not yet approved for clinical practice in the neo / adjuvant treatment of hormone receptor-positive breast cancer, this case report portrays a successful example of its application in a neoadjuvant setting.
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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 Limits: Adult / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: Portugal Institution/Affiliation country: Centro Hospitalar de Trás-os-Montes e Alto Douro EPE/PT

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Carcinoma / Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 Limits: Adult / Female / Humans Language: English Journal: Autops. Case Rep Journal subject: Anatomia / Patologia Cl¡nica / Patologia Legal Year: 2021 Type: Article Affiliation country: Portugal Institution/Affiliation country: Centro Hospitalar de Trás-os-Montes e Alto Douro EPE/PT