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Gut microbiota in Mexican patients with common variable immunodeficiency
Department of Clinical Allergy and ImmunologyFranco-Esquivias, Ana Paola; García-De la Peña, Cristina; Department of Clinical Allergy and ImmunologyTorres-Lozano, Carlos; Vaca-Paniagua, Felipe; Díaz-Velásquez, Clara; Department of Clinical Allergy and ImmunologyOrtega-Cisneros, Margarita; Physiology DepartmentQuintero-Ramos, Antonio.
  • Department of Clinical Allergy and ImmunologyFranco-Esquivias, Ana Paola; Instituto Mexicano del Seguro Social. Specialty Hospital. Department of Clinical Allergy and ImmunologyFranco-Esquivias, Ana Paola. Guadalajara. MX
  • García-De la Peña, Cristina; Universidad Juárez del Estado de Durango. Faculty of Biological Sciences. Laboratory of Preservation Medicine. Durango. MX
  • Department of Clinical Allergy and ImmunologyTorres-Lozano, Carlos; Instituto Mexicano del Seguro Social. Specialty Hospital. Department of Clinical Allergy and ImmunologyTorres-Lozano, Carlos. Guadalajara. MX
  • Vaca-Paniagua, Felipe; Universidad Nacional Autónoma de México. Iztacala Higher Education Faculty. Tlalnepantla. MX
  • Díaz-Velásquez, Clara; Universidad Nacional Autónoma de México. Iztacala Higher Education Faculty. Tlalnepantla. MX
  • Department of Clinical Allergy and ImmunologyOrtega-Cisneros, Margarita; Instituto Mexicano del Seguro Social. Specialty Hospital. Department of Clinical Allergy and ImmunologyOrtega-Cisneros, Margarita. Guadalajara. MX
  • Physiology DepartmentQuintero-Ramos, Antonio; Universidad de Guadalajara. Health Sciences University Center. Physiology DepartmentQuintero-Ramos, Antonio. Guadalajara. MX
Gac. méd. Méx ; 155(5): 447-452, Sep.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1286541
ABSTRACT

Introduction:

Common variable immunodeficiency (CVID) is the main symptomatic primary immunodeficiency and is associated with complex immune disorders. Gut microbiota interacts closely with the immune system, and intestinal dysbiosis is related to multiple diseases.

Objective:

To describe for the first time the composition of gut microbiota in Mexican patients with CVID.

Methods:

Fecal samples from five patients with CVID were collected and massive sequencing of the V3-V4 region of 16S rRNA gene was carried out using illumina technology.

Results:

Bacterial relative abundance was observed at all taxonomic levels. Firmicutes, Actinobacteria and Verrucomicrobia were the predominant phyla. The Clostridia class and the Clostridial order were the most common in their respective taxon; the Ruminococcaceae family predominated. A total of 166 genera were reported, with the most abundant being Faecalibacterium. Five species were identified, but only Bifidobacterium longum was present in all patients.

Conclusions:

Unlike healthy subjects' gut microbiota, where Firmicutes and Bacteroidetes predominate, the microbiota of the patients with CVID considered in this study was abundant in Firmicutes, Actinobacteria and Verrucomicrobia. The low presence of Bacteroidetes and high abundance of Firmicutes might indicate the existence of intestinal dysbiosis in these patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Common Variable Immunodeficiency / Gastrointestinal Microbiome Type of study: Prognostic study Limits: Adult / Humans Country/Region as subject: Mexico Language: English Journal: Gac. méd. Méx Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX / Universidad Juárez del Estado de Durango/MX / Universidad Nacional Autónoma de México/MX / Universidad de Guadalajara/MX

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Full text: Available Index: LILACS (Americas) Main subject: Common Variable Immunodeficiency / Gastrointestinal Microbiome Type of study: Prognostic study Limits: Adult / Humans Country/Region as subject: Mexico Language: English Journal: Gac. méd. Méx Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Mexicano del Seguro Social/MX / Universidad Juárez del Estado de Durango/MX / Universidad Nacional Autónoma de México/MX / Universidad de Guadalajara/MX