Relationship of the low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index with antioxidant enzymes and with the oxLDL/HDL index
Gac. méd. Méx
;
155(5): 453-457, Sep.-Oct. 2019. tab
Article
in English
| LILACS
| ID: biblio-1286542
ABSTRACT
Introduction:
The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications.Objective:
To assess the association of the index with oxidative stress markers.Methods:
444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase, glutathione peroxidase 3 (GPx3), magnesium and oxidized LDL (oxLDL) index (oxLDL/HDL) were quantified.Results:
A decrease of 1.014 units in the LDL/HDL index was associated with a superoxide dismutase increase of 1 unit/mL (p = 0.030), while a decrease of 0.023 units was associated with a GPx3 increase of 1 nmol/min/mL (p < 0.0005). An increase of one unit in the index was associated with an increase of 0.831 in the oxLDL/HDL index (p < 0.05). After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 µg/g of magnesium in the nails (p = 0.020).Conclusions:
The LDL/HDL index shows an inverse relationship with the antioxidant status and a direct relationship with oxidation status, regardless of other cardiovascular and oxidative stress risk factors.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Superoxide Dismutase
/
Oxidative Stress
/
Glutathione Peroxidase
/
Lipoproteins, HDL
/
Lipoproteins, LDL
Type of study:
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Gac. méd. Méx
Journal subject:
Medicine
Year:
2019
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Benemérita Universidad Autónoma de Puebla/MX
/
Instituto Mexicano del Seguro Social/MX
/
Instituto Politécnico Nacional/MX
/
Universidad Autónoma del Estado de Morelos/MX
Similar
MEDLINE
...
LILACS
LIS