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Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies
Wu, Jing; Yang, Nan; Yuan, Mingxin.
  • Wu, Jing; Second Affiliated Hospital of Harbin Medical University. Department of Cadre Ward. Harbin. CN
  • Yang, Nan; Second Affiliated Hospital of Harbin Medical University. Department of Cadre Ward. Harbin. CN
  • Yuan, Mingxin; Second Affiliated Hospital of Harbin Medical University. Department of Cadre Ward. Harbin. CN
Int. braz. j. urol ; 47(4): 733-744, Jul.-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286760
ABSTRACT
ABSTRACT

Objective:

This meta-analysis is the first to evaluate the associations of circulating and dietary intake of vitamin D with risk of risk of renal cell carcinoma (RCC). Our findings showed that higher circulating vitamin D level and dietary vitamin D intake were associated with a reduced risk of RCC. The possible explanation might be attributed to the anti-inflammatory effect, inhibiting cell proliferation, inducing cell differentiation and apoptosis. Materials and

Methods:

We searched the MEDLINE, EMBASE, and Scopus databases from their inception points through December 2018 for observational studies. The pooled relative risks (RRs) with corresponding 95% CIs were calculated using random-effects or fixed-effects models. The Newcastle-Ottawa scale was employed to assess the quality of the included studies.

Results:

A total of 9 publications were included in this meta-analysis. An overall analysis of the highest versus lowest intake levels revealed that circulating vitamin D level was protectively associated with risk of RCC 0.76 (95% CI 0.64-0.89, P=0.001), with no evidence of heterogeneity (I2=38.8%, P=0.162). In addition, dietary vitamin D intake was associated with a reduced risk of RCC (RR 0.86; 95% CI 75-0.99, P=0.030). Statistical heterogeneity was not identified (I2=28.8%, P=0.199). Subgroup analyses results showed the gender differences, and the associations were significant in results with women participants (RR 0.70; 95% CI 0.55-0.88) and case-control studies (RR 0.80, 95% CI 0.67-0.95).

Conclusion:

Higher circulating vitamin D level and higher dietary vitamin D intake both might be associated with a reduced risk of RCC. Further high-quality randomized controlled trials are required in the future to confirm our results.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Kidney Neoplasms Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Second Affiliated Hospital of Harbin Medical University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma, Renal Cell / Kidney Neoplasms Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors / Systematic reviews Limits: Female / Humans Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Second Affiliated Hospital of Harbin Medical University/CN