Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies
Int. braz. j. urol
;
47(4): 733-744, Jul.-Aug. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1286760
ABSTRACT
ABSTRACT Objective:
This meta-analysis is the first to evaluate the associations of circulating and dietary intake of vitamin D with risk of risk of renal cell carcinoma (RCC). Our findings showed that higher circulating vitamin D level and dietary vitamin D intake were associated with a reduced risk of RCC. The possible explanation might be attributed to the anti-inflammatory effect, inhibiting cell proliferation, inducing cell differentiation and apoptosis. Materials andMethods:
We searched the MEDLINE, EMBASE, and Scopus databases from their inception points through December 2018 for observational studies. The pooled relative risks (RRs) with corresponding 95% CIs were calculated using random-effects or fixed-effects models. The Newcastle-Ottawa scale was employed to assess the quality of the included studies.Results:
A total of 9 publications were included in this meta-analysis. An overall analysis of the highest versus lowest intake levels revealed that circulating vitamin D level was protectively associated with risk of RCC 0.76 (95% CI 0.64-0.89, P=0.001), with no evidence of heterogeneity (I2=38.8%, P=0.162). In addition, dietary vitamin D intake was associated with a reduced risk of RCC (RR 0.86; 95% CI 75-0.99, P=0.030). Statistical heterogeneity was not identified (I2=28.8%, P=0.199). Subgroup analyses results showed the gender differences, and the associations were significant in results with women participants (RR 0.70; 95% CI 0.55-0.88) and case-control studies (RR 0.80, 95% CI 0.67-0.95).Conclusion:
Higher circulating vitamin D level and higher dietary vitamin D intake both might be associated with a reduced risk of RCC. Further high-quality randomized controlled trials are required in the future to confirm our results.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carcinoma, Renal Cell
/
Kidney Neoplasms
Type of study:
Controlled clinical trial
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Female
/
Humans
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2021
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Second Affiliated Hospital of Harbin Medical University/CN
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