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DD Genotype and Atherosclerosis in Overweight Menopausal Women
Lanz-Luces, José Ramón; Costa, Fernando Alves; Guzman, Luis Fernando Escobar; Gagliardi, Antonio Ricardo de Toledo; Lanz-Luces, José Antonio; Lanz-Souquett, José Daniel; Costa, Leandro Menezes Alves da.
  • Lanz-Luces, José Ramón; Universidade de São Paulo. Instituto do Coração. São Paulo. BR
  • Costa, Fernando Alves; Instituto Paulista de Doenças Cardiovasculares. São Paulo. BR
  • Guzman, Luis Fernando Escobar; Universidade de São Paulo. Instituto do Coração. São Paulo. BR
  • Gagliardi, Antonio Ricardo de Toledo; Universidade de São Paulo. Instituto do Coração. São Paulo. BR
  • Lanz-Luces, José Antonio; Instituto Paulista de Doenças Cardiovasculares. São Paulo. BR
  • Lanz-Souquett, José Daniel; Instituto Paulista de Doenças Cardiovasculares. São Paulo. BR
  • Costa, Leandro Menezes Alves da; Instituto Paulista de Doenças Cardiovasculares. São Paulo. BR
Int. j. cardiovasc. sci. (Impr.) ; 34(4): 411-419, July-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1286822
ABSTRACT
Abstract Background Sex-specific pathology of coronary artery disease (CAD) has not been recognized. Women with obstructive or nonobstructive CAD associated with traditional risk factors have similar events; no studies have explored both populations in association with genetic markers. Objective To evaluate the DD genotype in overweight menopausal women and its association with CAD and traditional risk factors. Method This cross-sectional study included 356 menopausal women who underwent coronary angiography as CAD assessment. The patients' DNA was extracted and polymorphisms were detected with a single polymerase chain reaction assay. Two groups were formed based on luminal lesions (normal [n = 134] or pathological [n = 222]) with a cutoff value > 30%, considering overweight and age. The chi-square test, Student's t-test, and multivariate logistic regression were performed as appropriate (p < 0.05) using the following variables overweight, diabetes, hypertension, dyslipidemia, smoking status, sedentary lifestyle, and a family history of CAD. Results The mean age of the sample was 63 + 8 years, and the mean BMI was 28 + 5 kg/m2. The DD genotype was slightly more prevalent in the pathological group (30.2% vs. 21.6%, p = 0.079), but this significantly changed when BMI > 25 was considered (33% vs. 18%, p = 0.012). In multivariate analysis with two threshold levels (> 50 and > 60 years), diabetes was significantly associated with CAD in both models (p = 0.021 vs. 0.009) but the genotype was only associated with younger age (p = 0.034). Conclusion These data support an association between atherosclerosis and the renin-angiotensin system in overweight menopausal women that is dependent on the age at which the ischemic event occurs.
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Full text: Available Index: LILACS (Americas) Main subject: Coronary Artery Disease / Genetic Markers / Atherosclerosis Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Int. j. cardiovasc. sci. (Impr.) Journal subject: Cardiology Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Paulista de Doenças Cardiovasculares/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Coronary Artery Disease / Genetic Markers / Atherosclerosis Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans Language: English Journal: Int. j. cardiovasc. sci. (Impr.) Journal subject: Cardiology Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Instituto Paulista de Doenças Cardiovasculares/BR / Universidade de São Paulo/BR