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Cord blood bilirubin and prediction of neonatal hyperbilirubinemia and perinatal infection in newborns at risk of hemolysis
Kardum, Darjan; Serdarušić, Ivana; Biljan, Borna; Šantić, Krešimir; Živković, Vinko; Kos, Martina.
  • Kardum, Darjan; University Hospital Osijek. Department of Pediatrics. Osijek. HR
  • Serdarušić, Ivana; University Hospital Osijek. Department of Pediatrics. Osijek. HR
  • Biljan, Borna; University Hospital Osijek. Department of Pediatrics. Osijek. HR
  • Šantić, Krešimir; University Hospital Osijek. Department of Pediatrics. Osijek. HR
  • Živković, Vinko; University Hospital Osijek. Department of Pediatrics. Osijek. HR
  • Kos, Martina; University Hospital Osijek. Department of Pediatrics. Osijek. HR
J. pediatr. (Rio J.) ; 97(4): 440-444, July-Aug. 2021. tab
Article in English | LILACS | ID: biblio-1287036
ABSTRACT
Abstract Objective To assess the accuracy of umbilical cord bilirubin values to predict jaundice in the first 48 h of life and neonatal infection. Method Newborn infants treated at a regional well-baby nursery born at ≥36 weeks of gestation were included in this retrospective cohort study. All infants born in a 3-year period from mothers with O blood type and/or Rh-negative were included and had the umbilical cord bilirubin levels measured. Hyperbilirubinemia in the first 48 h was defined as bilirubin levels above the phototherapy threshold. Neonatal infection was defined as any antibiotic treatment before discharge. Results A total of 1360 newborn infants were included. Two hundred and three (14.9%) newborn infants developed hyperbilirubinemia in the first 48 h of life. Hyperbilirubinemic infants had smaller birth weight, higher levels of umbilical cord bilirubin, a higher rate of infection and were more often direct antiglobulin test positive. Umbilical cord bilirubin had a sensitivity of 76.85% and a specificity of 69.58% in detecting hyperbilirubinemia in the first 48 h, with the cut-off value at 34 µmol/L. The area under the receiver operating characteristic curve was 0.80 (95% CI 0.78-0.82). Umbilical cord bilirubin had a sensitivity of 27.03% and specificity of 91.31% in detecting perinatal infection. The area under the receiver operating characteristic (ROC) curve was 0.59 (95% CI 0.57-0.63). Conclusions A positive correlation was found between umbilical cord bilirubin and hyperbilirubinemia in the first 48 h of life. Umbilical cord bilirubin is a poor marker for predicting neonatal infection.
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Full text: Available Index: LILACS (Americas) Main subject: Bilirubin / Hyperbilirubinemia, Neonatal Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant / Infant, Newborn Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Croatia Institution/Affiliation country: University Hospital Osijek/HR

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Full text: Available Index: LILACS (Americas) Main subject: Bilirubin / Hyperbilirubinemia, Neonatal Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Female / Humans / Infant / Infant, Newborn Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2021 Type: Article Affiliation country: Croatia Institution/Affiliation country: University Hospital Osijek/HR