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Dengue fever as a potential cause of sickle cell intrahepatic cholestasis: A report of two cases
Oliveira, Leonardo Rodrigues de; Costa, Ana Laura Castro; Almeida, Paula Veloso; Zago, Luzia Beatriz Ribeiro; Silva, Vanessa Afonso da; Soares-Silva, Sheila.
  • Oliveira, Leonardo Rodrigues de; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
  • Costa, Ana Laura Castro; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
  • Almeida, Paula Veloso; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
  • Zago, Luzia Beatriz Ribeiro; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
  • Silva, Vanessa Afonso da; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
  • Soares-Silva, Sheila; Universidade Federal do Triângulo Mineiro. Serviço de Hematologia e Hemoterapia. Uberaba. BR
Rev. Soc. Bras. Med. Trop ; 54: e00102021, 2021. tab
Article in English | LILACS | ID: biblio-1288093
ABSTRACT
Abstract Sickle cell intrahepatic cholestasis is a potentially fatal syndrome characterized by jaundice, painful hepatomegaly, and organ dysfunction. Two cases of sickle cell intrahepatic cholestasis associated with dengue fever were described. Endothelial damage/dysfunction is a mechanism involved in severe hepatobiliary complications related to sickle cell diseases. However, the reasons for the lack of increase in the admission of patients with sickle cell disease having severe acute hepatobiliary complications triggered by endothelial damage/dysfunction due to dengue fever remain unknown. This study describes the first association between sickle cell intrahepatic cholestasis and dengue fever.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cholestasis, Intrahepatic / Dengue / Anemia, Sickle Cell Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cholestasis, Intrahepatic / Dengue / Anemia, Sickle Cell Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal do Triângulo Mineiro/BR