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Evaluation of the royal free hospital cirrhosis glomerular filtration rate formula in hispanic patients with cirrhosis: an external validation
Tejeda-Maldonado, Javier; Niño-Cruz, José A.; Cruz-Rivera, Cristino; Torre, Aldo; Aguirre-Valadez, Jonathan.
  • Tejeda-Maldonado, Javier; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Nephrology and Mineral Metabolism. Mexico City. MX
  • Niño-Cruz, José A.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Nephrology and Mineral Metabolism. Mexico City. MX
  • Cruz-Rivera, Cristino; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Nephrology and Mineral Metabolism. Mexico City. MX
  • Torre, Aldo; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Gastroenterology. Mexico City. MX
  • Aguirre-Valadez, Jonathan; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Gastroenterology. Mexico City. MX
Rev. invest. clín ; 71(3): 195-203, May.-Jun. 2019. tab, graf
Article in English | LILACS | ID: biblio-1289687
ABSTRACT
Abstract Background and Aims Glomerular filtration rate (GFR) measurement in patients with liver cirrhosis (LC) is the ideal method for adequate evaluation of kidney function. However, it is invasive, costly, and not widely accessible. Moreover, GFR estimation in patients with cirrhosis has been inaccurate. The aim of the present study was to evaluate and validate the recently described Royal Free Hospital (RFH) formula in a Hispanic cohort of patients with LC and compare it with other formulas, including the CKD-EPI cystatin C equation. Methods GFR was measured through the renal clearance of Tc-99m DTPA; it was cross-sectionally evaluated and compared with GFRs that were estimated utilizing the following formulas RFH, Cockcroft-Gault, 6-variable Modification of Diet in Renal Disease-6, CKD-EPI cystatin C, CKD-EPI Creatinine, and CKD-EPI Cystatin C-Creatinine. Results We included 76 patients (53% women). The mean measured GFR in the entire cohort was 64 ml/min/1.73m2; 54% of the patients had a GFR < 60 ml/min/1.73 m2 at the time of evaluation. The RFH formula and the CKD-EPI cystatin C formula showed the best performance, with a p30 of 62% and 59%, respectively. All formulas performed poorly when GFR was < 60 ml/min/1.73 m2. Conclusions The RFH formula showed a better performance than the other formulas based on serum creatinine in a Hispanic population with LC. There was no difference in performance between the RFH formula and the CKD-EPI cystatin C formula.
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Full text: Available Index: LILACS (Americas) Main subject: Glomerular Filtration Rate / Kidney Diseases / Kidney Function Tests / Liver Cirrhosis Type of study: Etiology study / Incidence study / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX

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Full text: Available Index: LILACS (Americas) Main subject: Glomerular Filtration Rate / Kidney Diseases / Kidney Function Tests / Liver Cirrhosis Type of study: Etiology study / Incidence study / Observational study / Prevalence study / Risk factors Limits: Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX