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Insulin-like growth factor binding protein-1, non-alcoholic fatty liver disease, and its relationship with fructose consumption in children with obesity
Flores-Ramírez, Anaisa G.; Ibarra-Reynoso, Lorena del R.; López-Lemus, Hilda Lissete; Olvera-Juárez, Montserrat; Luevano-Contreras, Claudia; Garay-Sevilla, Ma. Eugenia.
  • Flores-Ramírez, Anaisa G.; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
  • Ibarra-Reynoso, Lorena del R.; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
  • López-Lemus, Hilda Lissete; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
  • Olvera-Juárez, Montserrat; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
  • Luevano-Contreras, Claudia; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
  • Garay-Sevilla, Ma. Eugenia; University of Guanajuato. Department of Medical Sciences. Guanajuato. MX
Rev. invest. clín ; 71(5): 339-348, Sep.-Oct. 2019. tab, graf
Article in English | LILACS | ID: biblio-1289704
ABSTRACT
Background Over consumption of added sugar is associated with obesity, non-alcoholic fatty liver disease (NAFLD), and insulin resistance (IR). Objective The objective of the study was to study the insulin-like growth factor binding protein-1 (IGFBP-1) and NAFLD and their relationship with fructose consumption in children with obesity. Methods A cross-sectional study was carried out in children 6-11 years old with obesity. Anthropometric measurements, fructose consumption, glucose, lipid profile, insulin, and IGFBP-1 levels were evaluated; the homeostatic model assessment of IR (HOMA-IR) was used. NAFLD was evaluated by ultrasound. Results We studied 83 children with a mean age of 9.2 ± 1.3 years. About 93% of the girls presented IR and lower levels of IGFBP-1 (p = 0.0001). The group with the lower levels of IGFBP-1 had higher HOMA-IR (p = 0.000002); IGFBP-1 was associated with fructose consumption (r = −0.25; p = 0.03), body mass index (BMI) (r=−0.42; p = 0.02), and HOMA-IR (r=−0.61; p = 0.002). About 81% of the children were classified as having mild or moderate/severe NAFLD, and these groups had higher HOMA-IR (p = 0.036) and fructose consumption (p = 0.0014). Conclusions The girls had more metabolic alterations. The group with lower levels of IGFBP-1 (hepatic IR) was associated with higher BMI, HOMA-IR, and fructose consumption; the group with higher severity of NAFLD showed higher HOMA-IR and fructose consumption.
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Full text: Available Index: LILACS (Americas) Main subject: Insulin-Like Growth Factor Binding Protein 1 / Pediatric Obesity / Non-alcoholic Fatty Liver Disease / Fructose Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: University of Guanajuato/MX

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Full text: Available Index: LILACS (Americas) Main subject: Insulin-Like Growth Factor Binding Protein 1 / Pediatric Obesity / Non-alcoholic Fatty Liver Disease / Fructose Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Child / Female / Humans / Male Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: University of Guanajuato/MX