Your browser doesn't support javascript.
loading
Association of vitamin d with mild cognitive impairment and alzheimer's dementia in older mexican adults
Aguilar-Navarro, Sara G.; Mimenza-Alvarado, Alberto J.; Jiménez-Castillo, Gilberto A.; Bracho-Vela, Leonardo A.; Yeverino-Castro, Sara G.; Ávila-Funes, José A..
  • Aguilar-Navarro, Sara G.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Geriatric Medicine and Neurology Fellowship Program. Mexico City. MX
  • Mimenza-Alvarado, Alberto J.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Geriatric Medicine and Neurology Fellowship Program. Mexico City. MX
  • Jiménez-Castillo, Gilberto A.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Geriatric Medicine and Neurology Fellowship Program. Mexico City. MX
  • Bracho-Vela, Leonardo A.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Geriatric Medicine and Neurology Fellowship Program. Mexico City. MX
  • Yeverino-Castro, Sara G.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Geriatric Medicine and Neurology Fellowship Program. Mexico City. MX
  • Ávila-Funes, José A.; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Department of Geriatrics. Mexico City. MX
Rev. invest. clín ; 71(6): 381-386, Nov.-Dec. 2019. tab
Article in English | LILACS | ID: biblio-1289709
ABSTRACT
ABSTRACT Background It has been proposed that Vitamin D helps reduce the accumulation of cerebral β-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer’s dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (> 65 years) Methods Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels sufficiency (> 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed Results We evaluated 208 patients. Mean age was 79 ± 1 year, 65% (n = 136) were female; and mean educational level was 6.7 ± 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p < 0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p < 0.001) and AD (HR 41.7 [5.76-301]; p < 0.001) after adjusting for confounders Conclusions Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Vitamin D Deficiency / Alzheimer Disease Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Vitamin D / Vitamin D Deficiency / Alzheimer Disease Type of study: Etiology study / Observational study / Prevalence study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Mexico Language: English Journal: Rev. invest. clín Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Mexico Institution/Affiliation country: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán/MX