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Prognostic significance of the mad1l1 1673 g:a polymorphism in ovarian adenocarcinomas
Bandala-Jacques, Antonio; Hernández-Cruz, Irwin A.; Castro-Hernández, Clementina; Díaz-Chávez, José; Arriaga-Canon, Cristian; Barquet-Muñoz, Salim A.; Prada-Ortega, Diddier G.; Cantú-de León, David; Herrera, Luis A..
Affiliation
  • Bandala-Jacques, Antonio; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Hernández-Cruz, Irwin A.; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Castro-Hernández, Clementina; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Díaz-Chávez, José; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Arriaga-Canon, Cristian; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Barquet-Muñoz, Salim A.; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Prada-Ortega, Diddier G.; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Cantú-de León, David; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
  • Herrera, Luis A.; Universidad Nacional Autónoma de México. Instituto de Investigaciones Biomédicas. Mexico City. MX
Rev. invest. clín ; 72(6): 372-379, Nov.-Dec. 2020. tab, graf
Article in En | LILACS | ID: biblio-1289732
Responsible library: BR1.1
ABSTRACT
Abstract

Background:

Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic spindle assembly checkpoint by preventing anaphase until all chromatids are properly aligned. A single-nucleotide polymorphism in the MAD1L1 gene is prevalent in patients with advanced epithelial ovarian cancer and alters the way in which it responds to chemotherapy.

Objective:

The objective of the study was to study the relationship between the rs1801368 polymorphism of MAD1L1 and prognosis of ovarian adenocarcinoma.

Methods:

A total of 118 patients in whom the MAD1L1 gene was sequenced were analyzed using descriptive and comparative statistics.

Results:

Patients carrying the wild-type genotype had a higher distribution of early-stage disease. Having a MAD1L1 polymorphic allele increased the risk of being non-sensitive to chemotherapy. The median disease-free survival for patients with the wild-type MAD1L1 was 46.93 months, compared to 10.4 months for patients with at least one polymorphic allele.

Conclusions:

The rs1801368 polymorphism of MAD1L1 gene worsens prognosis in patients with ovarian adenocarcinoma. Traditional therapy for ovarian cancer might not be optimal in patients carrying this polymorphism.
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Full text: 1 Index: LILACS Main subject: Ovarian Neoplasms / Adenocarcinoma / Cell Cycle Proteins / Polymorphism, Single Nucleotide Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans Language: En Journal: Rev. invest. clín Journal subject: MEDICINA Year: 2020 Type: Article

Full text: 1 Index: LILACS Main subject: Ovarian Neoplasms / Adenocarcinoma / Cell Cycle Proteins / Polymorphism, Single Nucleotide Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Female / Humans Language: En Journal: Rev. invest. clín Journal subject: MEDICINA Year: 2020 Type: Article