Association between handgrip strength and bone mass parameters in HIV-infected children and adolescents. A cross-sectional study
São Paulo med. j
;
139(4): 405-411, Jul.-Aug. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1290245
ABSTRACT
ABSTRACT BACKGROUND:
Low bone mineral content (BMC) and bone mineral density (BMD) have been identified in human immunodeficiency virus (HIV)-infected children and adolescents. The direct adverse effects of HIV infection and combined antiretroviral therapy (ART) negatively contribute to bone metabolism. A direct relationship between muscle strength levels and BMD in HIV-infected adults and older adults has been described. However, it is unknown whether handgrip strength (HGS) is associated with bone mass in pediatric populations diagnosed with HIV.OBJECTIVE:
To ascertain whether HGS levels are associated with BMC and BMD in HIV-infected children and adolescents. DESIGN ANDSETTING:
Cross-sectional study conducted in Florianãpolis, Brazil, in 2016.METHODS:
The subjects were 65 children and adolescents (8-15 years) diagnosed with vertically-transmitted HIV. Subtotal and lumbar-spine BMC and BMD were obtained via dual-emission X-ray absorptiometry (DXA). HGS was measured using manual dynamometers. The covariates of sex, ART, CD4+ T lymphocytes and viral load were obtained through questionnaires and medical records. Sexual maturation was self-reported and physical activity was measured using accelerometers. Simple and multiple linear regression were used, with P < 0.05.RESULTS:
HGS was directly associated with subtotal BMD (β = 0.002; R² = 0.670; P < 0.001), subtotal BMC (β = 0.090; R² = 0.734; P = 0.005) and lumbar-spine BMC (β = 1.004; R² = 0.656; P = 0.010) in the adjusted analyses. However, no significant association was found between HGS and lumbar-spine BMD (β = 0.001; R² = 0.464; P = 0.299).CONCLUSION:
HGS was directly associated with BMD and BMC in HIV-infected children and adolescents.
Full text:
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Index:
LILACS (Americas)
Main subject:
Bone Density
/
HIV Infections
Type of study:
Practice guideline
/
Observational study
/
Prevalence study
/
Risk factors
Limits:
Adolescent
/
Aged
/
Child
/
Humans
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Physical Education/BR
/
Instituto de Educação Física e Esporte (IEFE)/BR
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