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Lung function and stress echocardiography in pulmonary arterial hypertension: a cross-sectional study
de Almeida, Guilherme Casagrande; University of Campinas (UNICAMP)Pereira, Mônica Corso; University of Campinas (UNICAMP)Moreira, Marcos Mello; University of Campinas (UNICAMP)Souza, José Roberto Matos; University of Campinas (UNICAMP)Paschoal, Ilma Aparecida.
  • de Almeida, Guilherme Casagrande; Paulista University. Department of Physical Therapy. Campinas. BR
  • University of Campinas (UNICAMP)Pereira, Mônica Corso; Discipline of Pulmonology, Department of Internal Medicine. School of Medical Sciences (FCM). University of Campinas (UNICAMP)Pereira, Mônica Corso. Campinas. BR
  • University of Campinas (UNICAMP)Moreira, Marcos Mello; Discipline of Pulmonology, Department of Internal Medicine, and Professor of Postgraduate Program on Surgical Sciences. School of Medical Sciences (FCM). University of Campinas (UNICAMP)Moreira, Marcos Mello. Campinas. BR
  • University of Campinas (UNICAMP)Souza, José Roberto Matos; Discipline of Cardiology, Department of Internal Medicine. School of Medical Sciences (FCM). University of Campinas (UNICAMP)Souza, José Roberto Matos. Campinas. BR
  • University of Campinas (UNICAMP)Paschoal, Ilma Aparecida; Discipline of Pulmonology, Department of Internal Medicine. School of Medical Sciences (FCM). University of Campinas (UNICAMP)Paschoal, Ilma Aparecida. Campinas. BR
São Paulo med. j ; 139(5): 505-510, May 2021. tab
Article in English | LILACS | ID: biblio-1290253
ABSTRACT
ABSTRACT

BACKGROUND:

The mechanism of exercise limitation in idiopathic pulmonary arterial hypertension (IPAH) is not fully understood. The role of hemodynamic alterations is well recognized, but mechanical, ventilatory and gasometric factors may also contribute to reduction of exercise capacity in these individuals.

OBJECTIVE:

To investigate whether there is an association between ventilatory pattern and stress Doppler echocardiography (SDE) variables in IPAH patients. DESIGN AND

SETTING:

Single-center prospective study conducted in a Brazilian university hospital.

METHODS:

We included 14 stable IPAH patients and 14 age and sex-matched controls. Volumetric capnography (VCap), spirometry, six-minute walk test and SDE were performed on both the patients and the control subjects. Arterial blood gases were collected only from the patients. The IPAH patients and control subjects were compared with regard to the abovementioned variables.

RESULTS:

The mean age of the patients was 38.4 years, and 78.6% were women. The patients showed hypocapnia, and in spirometry 42.9% presented forced vital capacity (FVC) below the lower limit of normality. In VCap, IPAH patients had higher respiratory rates (RR) and lower elimination of CO2 in each breath. There was a significant correlation between reduced FVC and the magnitude of increases in tricuspid regurgitation velocity (TRV). In IPAH patients, VCap showed similar tidal volumes and a higher RR, which at least partially explained the hypocapnia.

CONCLUSIONS:

The patients with IPAH showed hypocapnia, probably related to their higher respiratory rate with preserved tidal volumes; FVC was reduced and this reduction was positively correlated with cardiac output.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Arterial Hypertension Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Discipline of Cardiology, Department of Internal Medicine/BR / Discipline of Pulmonology, Department of Internal Medicine/BR / Discipline of Pulmonology, Department of Internal Medicine, and Professor of Postgraduate Program on Surgical Sciences/BR / Paulista University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Arterial Hypertension Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Discipline of Cardiology, Department of Internal Medicine/BR / Discipline of Pulmonology, Department of Internal Medicine/BR / Discipline of Pulmonology, Department of Internal Medicine, and Professor of Postgraduate Program on Surgical Sciences/BR / Paulista University/BR