Patogenia de la infección por SARS-CoV-2 / Pathogenesis of SARS-CoV-2 infection
Rev. Hosp. Clin. Univ. Chile
;
32(2): 107-117, 2021. ilus, tab
Article
in Spanish
| LILACS
| ID: biblio-1290954
ABSTRACT
Covid-19 is an infectious disease whose etiological agent called SARS-CoV-2. It has a high contagion rate, high morbidity and mortality, and potential multi-organ compromise. Its main route of infection is by droplets, however, the infection can be acquired by other routes such as aerosols, fecal-oral and contact with fomites. Although the immune response is essential for defense against any infection, in severe Covid-19 infection, a dysregulation of the immune system occurs, which leads to marked increases of cytokines and the consequent systemic inflammatory state. Inflammation, infection, and viral shedding can compromise the lungs, blood vessels, brain, gastrointestinal (GI) tract, kidneys, heart, and liver, ultimately leading to multiple organ dysfunction and failure. (AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
SARS-CoV-2
/
COVID-19
Type of study:
Etiology study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. Hosp. Clin. Univ. Chile
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico de la Universidad de Chile/CL
/
Universidad de Valparaiso/CL
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