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Amisulprida una nueva profilaxis contra las náuseas y vómitos postoperatorios: una revisión de la literatura / Amisulpride new prophylaxis against postoperative nausea and vomiting: a review of the literature
Gonzalez, Cecilia; Garchitorena, Maria Jesus; Sabat, Karime.
  • Gonzalez, Cecilia; Pontificia Universidad Católica de Chile. Facultad de Medicina. Santiago. CL
  • Garchitorena, Maria Jesus; Pontificia Universidad Católica de Chile. Facultad de Medicina. Santiago. CL
  • Sabat, Karime; Pontificia Universidad Católica de Chile. Facultad de Medicina. Santiago. CL
ARS med. (Santiago, En línea) ; 46(1): 38-43, mar. 2021.
Article in Spanish | LILACS | ID: biblio-1293297
RESUMEN
Introducción: las náuseas y vómitos postoperatorios (PONV) son una complicación postoperatoria común de la anestesia, por lo que la búsqueda de nuevas profilaxis efectivas ha aumentado durante los últimos años, en este contexto se perfila como una opción efectiva el amisulprida, antipsicótico que actúa bloqueando los receptores dopaminérgicos D2 y D3, en dosis bajas. Métodos: se realizó una búsqueda en bases de datos establecidas como: Pubmed, Embase, Google Scholar, Medline y la Cochrane central registed of controlled trials. Con las siguientes definiciones clave: "NV" or "postoperative nausea and vomiting" or "postoperative nausea" or "postoperative vomiting" and "Amisulpride" or "APD421", con el fin de cumplir el objetivo general de verificar la efectividad de amisulprida como medicamento profiláctico en manejo de PONV. Resultados: se evaluaron 3 estudios multicéntricos randomizados controlados, con alto grado de confiabilidad y buena calidad metodológica. Se evidencia que el amisulprida es un medicamento profiláctico efectivo contra PONV y con buen perfil de seguridad. Discusión/Conclusión: el amisulprida es un medicamento profiláctico eficaz para prevención de PONV, en dosis óptima de 5 mg, administrado durante el intraoperatorio de cirugías electivas en que se utilice anestesia general en pacientes de moderado a alto riesgo de PONV según escala de Apfel.
ABSTRACT
Introduction: postoperative nausea and vomiting (PONV) are common postoperative complications of anaesthesia, that is why the search for new effective prophylaxis has increased in recent years. Between the drugs that have been tested for this purpose, Amisulpride, an antipsychotic that blocks D2 and D3 dopaminergic receptors, seems to be an effective option when used in low doses. Methods: This search was done by using databases such as Pubmed, Embase, Google Scholar, Medline and the Cochrane central register of controlled. With the following keywords: "NV" or "postoperative nausea and vomiting" or "postoperative nausea" or "postoperative vomiting" and"Amisulpride" or "APD421", with the purpose of verifying the effectiveness of Amisulpride as prophylactic medication in PONV man-agement, which is our main objective. Results: 3 randomised, controlled, multicenter, with high reliability and good methodological quality studies were evaluated. Evidence suggests that Amisulpride is effective as a prophylactic medication against PONV, and it also has a good safety profile. Discussion/Conclusion: Amisulpride administered in an optimal dose of 5 mg during intraoperative elective surgeries that required general anaesthesia, showed to be effective in preventing PONV as a prophylactic drug in patients with moderate to high risk of PONV according to the Apfel scale.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Antibiotic Prophylaxis / Postoperative Nausea and Vomiting / Amisulpride Type of study: Controlled clinical trial Language: Spanish Journal: ARS med. (Santiago, En línea) Journal subject: Ciˆncias da Sa£de / Medicina Year: 2021 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Antibiotic Prophylaxis / Postoperative Nausea and Vomiting / Amisulpride Type of study: Controlled clinical trial Language: Spanish Journal: ARS med. (Santiago, En línea) Journal subject: Ciˆncias da Sa£de / Medicina Year: 2021 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL