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Integration of heterologous bone matrix associated with polymethylmethacrylate in induced tibial bone defects. An experimental study in rabbits
De Freitas, Silvio Henrique; Müller, Alois Foltran; Fadel, Thaís Ribeiro; Bessi, Wellington Henrique; Dória, Renata Gebara Sampaio; Yamauchi, Kelly Cristiane Ito; Strefezzi, Ricardo De Francisco; Vidane, Atanásio Serafim; Fortulan, Carlos Alberto; Ambrósio, Carlos Eduardo.
  • De Freitas, Silvio Henrique; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Associate Professor. Veterinary Medicine Department. Pirassununga. BR
  • Müller, Alois Foltran; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Postgraduate Program in Animal Bioscience. Pirassununga. BR
  • Fadel, Thaís Ribeiro; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Postgraduate Program in Animal Bioscience. Pirassununga. BR
  • Bessi, Wellington Henrique; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Postgraduate Program in Animal Bioscience. Pirassununga. BR
  • Dória, Renata Gebara Sampaio; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Associate Professor. Veterinary Medicine Department. Pirassununga. BR
  • Yamauchi, Kelly Cristiane Ito; Faculty of Veterinary Medicine. Department of Veterinary Clinic and Surgery. Cuiaba. BR
  • Strefezzi, Ricardo De Francisco; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Associate Professor. Veterinary Medicine Department. Pirassununga. BR
  • Vidane, Atanásio Serafim; Eduardo Mondlane University. Faculty of Veterinary Medicine. Department of Clinics. Maputo. MZ
  • Fortulan, Carlos Alberto; Universidade de São Paulo. Department of Mechanical Engineering. Sao Carlos. BR
  • Ambrósio, Carlos Eduardo; Universidade de São Paulo. Faculty of Animal Sciences and Food Engineering. Associate Professor. Veterinary Medicine Department. Pirassununga. BR
Acta cir. bras ; 36(7): e360704, 2021. tab, graf
Article in English | LILACS, VETINDEX | ID: biblio-1339002
ABSTRACT
ABSTRACT Purpose To analyze and compare the reactions at the interface between the composite, composed of fragmented heterologous mineralized bone matrix (MOMHF) and polymethylmethacrylate (PMMA), and the rabbit's tibias, through macroscopic evaluation and scanning electron microscopy (SEM) in different periods. Methods In this study, 12 New Zealand adult rabbits were used (E1 n = 3, E2 n = 3, E3 n = 3 and E4 n = 3). They had the right tibial defects filled with composite and were evaluated immediately after surgery and at 30, 60, 90, and 120 days. Results The composites were incorporated and integrated into the recipient beds in 100% of the cases, defined by the MOMHF osseointegration and the PMMA fibrointegration, with no sign of infection, migration, or rejection. Conclusions The behavior of the composites in the recipient beds demonstrates that these biomaterials have the potential to be used in bone defect repairs, offering, thus, better quality of life to the orthopedic patient.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Bone Matrix / Polymethyl Methacrylate Type of study: Risk factors Language: English Journal: Acta cir. bras Year: 2021 Type: Article Institution/Affiliation country: Eduardo Mondlane University/MZ / Faculty of Veterinary Medicine/BR / Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Bone Matrix / Polymethyl Methacrylate Type of study: Risk factors Language: English Journal: Acta cir. bras Year: 2021 Type: Article Institution/Affiliation country: Eduardo Mondlane University/MZ / Faculty of Veterinary Medicine/BR / Universidade de São Paulo/BR