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Thyroglobulin/thyrotropin ratio for predicting long-term response in differentiated thyroid carcinoma: a retrospective study
Marchi Junior, Adriano Francisco De; Macedo, Ana Bárbara Trizzotti de; Soares, Carlos Segundo Paiva; Bolfi, Fernanda; Iessi, Mariana Riello Gomes; Oliveira, Cristiano Claudino de; Koga, Katia Hiromoto; Moriguchi, Sonia Marta; Tagliarini, José Vicente; Mazeto, Gláucia Maria Ferreira da Silva.
  • Marchi Junior, Adriano Francisco De; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Macedo, Ana Bárbara Trizzotti de; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Soares, Carlos Segundo Paiva; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço. Botucatu. BR
  • Bolfi, Fernanda; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Iessi, Mariana Riello Gomes; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
  • Oliveira, Cristiano Claudino de; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Patologia. Botucatu. BR
  • Koga, Katia Hiromoto; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Medicina Nuclear. Botucatu. BR
  • Moriguchi, Sonia Marta; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Medicina Nuclear. Botucatu. BR
  • Tagliarini, José Vicente; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço. Botucatu. BR
  • Mazeto, Gláucia Maria Ferreira da Silva; Universidade Estadual Paulista. Faculdade de Medicina de Botucatu. Departamento de Clínica Médica. Botucatu. BR
Arch. endocrinol. metab. (Online) ; 65(4): 428-435, July-Aug. 2021. tab, graf
Article in English | LILACS | ID: biblio-1339097
ABSTRACT
ABSTRACT

Objective:

Thyrotropin-stimulated thyroglobulin (STg) after total thyroidectomy is a prognosis marker for differentiated thyroid carcinoma (DTC). As Tg level is influenced by thyrotropin (TSH), perhaps the STg/TSH ratio is also a prognosis marker for these tumours. We aimed to compare STg/TSH ratio and first STg level in differentiated thyroid carcinoma patients for their ability to predict the long-term response to initial treatment. Subjects and

methods:

This retrospective study evaluated data from 181 DTC patients for first (1st) STg and STg/TSH ratio, at 1-3 months post-total thyroidectomy and before iodine-131 therapy, according to response to initial therapy [Excellent/Indeterminate or Incomplete (Biochemical/Structural)] observed at final evaluation, and with the survival time with excellent/indeterminate response.

Results:

Cases with incomplete response presented higher STg level [225.13 ± 585.26 ng/mL versus (vs) 20.4 ± 192.9 ng/mL; p < 0.001] and STg/TSH ratio (3.01 ± 7.8 vs 0.27 ± 2.58; p < 0.001). Cutoffs of 5 ng/mL for STg and 0.085 for STg/TSH displayed sensitivities of 76.7% and 76.9%, and specificities of 79.2% and 82.6%, respectively, in predicting response to therapy. Values below these cutoffs were associated with longer survival time in excellent/indeterminate response (140.4 vs 15.9 and 144.6 vs 15.9 months, respectively).

Conclusion:

STg/TSH ratio has a similar performance to the 1st STg in predicting long-term response to initial therapy.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Thyroglobulin / Thyroid Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Thyroglobulin / Thyroid Neoplasms Type of study: Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Arch. endocrinol. metab. (Online) Journal subject: Endocrinology / Metabolism Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual Paulista/BR