Your browser doesn't support javascript.
loading
Associação entre os Níveis Séricos de Elabela e Oclusão Total Crônica em Pacientes com Angina Pectoris Estável / Association Between Serum Elabela Levels and Chronic Totally Occlusion in Patients with Stable Angina Pectoris
Yavuz, Fethi; Kaplan, Mehmet.
  • Yavuz, Fethi; Adıyaman University Training and Research Hospital. Departamento de Cardiologia. Adıyaman. TR
  • Kaplan, Mehmet; Gaziantep University Medicine Faculty. Departamento de Cardiologia. Gaziantep. TR
Arq. bras. cardiol ; 117(3): 503-510, Sept. 2021. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1339182
RESUMO
Resumo Fundamento Os efeitos benéficos do elabela no sistema cardiovascular foram demonstrados em estudos.

Objetivo:

Comparar os níveis séricos de elabela de pacientes com oclusão total crônica (OTC) com pacientes controle com artérias coronárias normais e investigar se há correlação com o desenvolvimento colateral.

Métodos:

Estudo transversal e prospectivo. O estudo incluiu cinquenta pacientes (28,0% mulheres, idade média 61,6±7,3 anos) com OTC em pelo menos um vaso coronário e 50 pacientes (38% mulheres, idade média 60,7±6,38 anos) com artérias coronárias normais. Os pacientes do grupo OTC foram divididos em dois grupos Rentrop 0-1, composto por pacientes com fraco desenvolvimento colateral e Rentrop 2-3, composto por pacientes com bom desenvolvimento colateral. Além da idade, sexo, características demográficas e exames laboratoriais de rotina dos pacientes, foram medidos os níveis de elabela.

Resultados:

As características demográficas e os valores laboratoriais mostraram-se semelhantes em ambos os grupos. Ao passo que o nível médio de NT-proBNP e troponina estava maior no grupo OTC, o nível médio de elabela estava menor (p<0,05 para todos). Na análise de regressão multivariada, os níveis de NT-proBNP e elabela foram considerados preditores independentes para OTC. Além disso, o nível de elabela apresentou-se estatisticamente maior em pacientes do grupo Rentrop 2-3 em comparação com os pacientes do grupo Rentrop 0-1 (p<0,05).

Conclusões:

Em nosso estudo, mostramos que o nível médio de elabela estava baixo em pacientes com OTC em comparação com pacientes normais. Além disso, constatamos que o nível de elabela é inferior em pacientes com desenvolvimento colateral fraco em comparação com pacientes com bom desenvolvimento colateral. (Arq Bras Cardiol. 2021; [online].ahead print, PP.0-0)
ABSTRACT
Abstract

Background:

The beneficial effects of Elabela on the cardiovascular system have been shown in studies.

Objective:

To compare serum Elabela levels of chronic total occlusion (CTO) patients with control patients with normal coronary arteries, and to investigate whether there is a correlation with collateral development.

Methods:

The study was planned cross-sectionally and prospectively. Fifty patients (28.0% female, mean age 61.6±7.3years) with CTO in at least one coronary vessel and 50 patients (38% female, mean age 60,7±6.38 years) with normal coronary arteries were included in the study. Patients in the CTO group were divided into two groups as Rentrop 0-1, those with weak collateral development, and Rentrop 2-3 with good collateral development. In addition to the age, sex, demographic characteristics and routine laboratory tests of the patients, Elabela levels were measured.

Results:

Demographic characteristics and laboratory values were similar in both groups. While the mean NT-proBNP and troponin were higher in the CTO group, the Elabela mean was lower (p <0.05 for all). In the multivariate regression analysis, NT-proBNP and Elabela levels were found to be independent predictors for CTO. Also, Elabela level was found to be statistically higher in Rentrop class 2-3 patients compared to Rentrop class 0-1 patients (p<0.05).

Conclusion:

In our study, we showed that the average Elabela level was low in CTO patients compared to normal patients. In addition, we found the level of Elabela to be lower in patients with weak collateral development compared to patients with good collateral development. (Arq Bras Cardiol. 2021; [online].ahead print, PP.0-0)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Coronary Occlusion / Angina, Stable Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ad&#305;yaman University Training and Research Hospital/TR / Gaziantep University Medicine Faculty/TR

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Index: LILACS (Americas) Main subject: Coronary Occlusion / Angina, Stable Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Ad&#305;yaman University Training and Research Hospital/TR / Gaziantep University Medicine Faculty/TR