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Regorafenib Suppresses Migration of and Induces Cell Cycle Arrest and Apoptosis in MCF-7 Cells
Wang, Dawei; Fan, Ceji; Tang, Jun.
  • Wang, Dawei; Wuhan Huaxia University of Technology. School of Biological and Pharmaceutical Engineering. Wuhan. CN
  • Fan, Ceji; Wuhan Huaxia University of Technology. School of Biological and Pharmaceutical Engineering. Wuhan. CN
  • Tang, Jun; Wuhan Huaxia University of Technology. School of Biological and Pharmaceutical Engineering. Wuhan. CN
Braz. J. Pharm. Sci. (Online) ; 57: e18122, 2021. tab, graf
Article in English | LILACS | ID: biblio-1339306
ABSTRACT
This study investigated the mechanism underlying the suppression of estrogen receptor-positive MCF-7 cell growth by regorafenib. MCF-7 cells were treated with regorafenib, and the effect of regorafenib on multiple cancer-associated pathways was evaluated. Although regorafenib effectively inhibited the proliferation of MCF-7 cells, it had no effect on the proliferation of the normal breast epithelial cell line MCF10A. Regorafenib suppressed MCF-7 cell migration, probably by regulating the homeostatic expression of matrix metalloproteinases and the tissue inhibitor of MMPs. Furthermore, it upregulated p21 expression, downregulated cyclin B1 and cyclin D1 expresssions, and caused cell cycle arrest. In addition, regorafenib induced apoptosis in MCF-7 cells by reducing Mcl-1 expression and activating caspase signaling. These results demonstrate that regorafenib has the potential to be an effective drug for treating breast cancer
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Cell Cycle / MCF-7 Cells Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Wuhan Huaxia University of Technology/CN

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Full text: Available Index: LILACS (Americas) Main subject: Cell Cycle / MCF-7 Cells Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Wuhan Huaxia University of Technology/CN