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Investigation of the Effects of Glutens on Serum Interleukin-1 Beta and Tumor Necrosis Factor-Alpha Levels and the Immunohistochemical Distribution of CD3 and CD8 Receptors in the Small Intestine in Male Rats
Gümüş, Recep; Uslu, Sema; Aydoğdu, Uğur; İmik, Aybüke; Ekici, Mehmet.
  • Gümüş, Recep; Sivas Cumhuriyet University. Faculty of Veterinary Medicine. Department of Animal Nutrition and Nutritional Disorders. Sivas. TR
  • Uslu, Sema; Burdur Mehmet Akif Ersoy University. Faculty of Veterinary Medicine. Department of Histology and Embryology. Burdur. TR
  • Aydoğdu, Uğur; Balıkesir University. Faculty of Veterinary Medicine. Department of Internal Medicine. Balıkesir. TR
  • İmik, Aybüke; Eastern Mediterranean University. Faculty of Health Sciences. Department of Nutrition and Dietetics. Gazimağusa. TR
  • Ekici, Mehmet; Sivas Cumhuriyet University. Faculty of Veterinary Medicine. Department of Physiology. Sivas. TR
Braz. arch. biol. technol ; 64: e21210256, 2021. tab, graf
Article in English | LILACS | ID: biblio-1339311
ABSTRACT
Abstract While the role of cytokines in celiac disease has been investigated in detail, cytokine release in the event of the exposure of healthy subjects to glutens has only recently been studied. This study was aimed at determining the effects of corn and wheat glutens, incorporated as protein sources into the diet, on serum interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels and the immunohistochemical distribution of CD3 and CD8 receptors in the small intestine in male rats. The study material comprised 24 twenty-day-old male Wistar albino rats, which were randomly assigned in equal numbers to three groups (2 rats/replicate and 4 replicates/group). The feed rations provided to all three groups contained high levels of proteins, which were soybean meal, corn gluten and wheat gluten in the control, corn and wheat groups, respectively. The in Control, Corn and Wheat groups serum IL-1 beta and TNF-alpha levels respectively 55.83 - 46.37; 81.65 - 61.95 and 81.65-61.31 was determined but these differences were statistically insignificant. Furthermore, immunohistochemical examination demonstrated a mathematical increase to have occurred in the distribution of the CD3 and CD8 receptors in the duodenum, jejunum and ileum samples of the corn and wheat groups. In result, based on the findings obtained in this study, we suggest that the long-term feeding of rats on high levels of gluten causes systemic adverse effects.
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Full text: Available Index: LILACS (Americas) Main subject: Cytokines / Tumor Necrosis Factor-alpha / Interleukin-1beta / Glutens Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Balıkesir University/TR / Burdur Mehmet Akif Ersoy University/TR / Eastern Mediterranean University/TR / Sivas Cumhuriyet University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Cytokines / Tumor Necrosis Factor-alpha / Interleukin-1beta / Glutens Limits: Animals Language: English Journal: Braz. arch. biol. technol Journal subject: Biology Year: 2021 Type: Article Affiliation country: Turkey Institution/Affiliation country: Balıkesir University/TR / Burdur Mehmet Akif Ersoy University/TR / Eastern Mediterranean University/TR / Sivas Cumhuriyet University/TR