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Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review / Glicogênio sintase quinase-3 (GSK-3), uma enzima mágica: seu papel no diabetes mellitus e na homeostase da glicose: interações com fluoroquinolonas. Uma mini-revisão
Ullah, A; Ali, N; Ahmad, S; Rahman, S U; Alghamdi, S; Bannunah, A M; Ali, R; Aman, A; Khan, J; Hussain, H; Sahibzada, M U K.
  • Ullah, A; Shaheed Benazir Bhutto University. Department of Pharmacy. Dir Upper. PK
  • Ali, N; Khyber Medical University. Institute of Basic Medical Sciences,. Peshawar. PK
  • Ahmad, S; Shaheed Benazir Bhutto University. Department of Pharmacy. Dir Upper. PK
  • Rahman, S U; Shaheed Benazir Bhutto University. Department of Pharmacy. Dir Upper. PK
  • Alghamdi, S; Umm Al-Qura University. Faculty of Applied Medical Sciences. Laboratory Medicine Department. Makkah. SA
  • Bannunah, A M; Umm Al-Qura University. Common First year Deanship. Department of Basic Sciences. Makkah. SA
  • Ali, R; Khyber Medical University. Institute of Basic Medical Sciences,. Peshawar. PK
  • Aman, A; Shaheed Benazir Bhutto University. Department of Pharmacy. Dir Upper. PK
  • Khan, J; University of Malakand. Department of Pharmacy,. Chakdara Dir Lower. PK
  • Hussain, H; Shaheed Benazir Bhutto University. Department of Pharmacy. Dir Upper. PK
  • Sahibzada, M U K; Sarhad University of Science and Information Technology. Department of Pharmacy. Peshawar. PK
Braz. j. biol ; 83: e250179, 2023. graf
Article in English | LILACS, VETINDEX | ID: biblio-1339372
ABSTRACT
Abstract Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. The GSK-3, that is the key enzyme is normally showing its actions by various mechanisms that include its phosphorylation, formation of protein complexes, and other cellular distribution and thus it control and directly affects cellular morphology, its growth, mobility and apoptosis of the cell. Disturbances in the action of GSK-3 enzyme may leads to various disease conditions that include insulin resistance leading to diabetes, neurological disease like Alzheimer's disease and cancer. Fluoroquinolones are the most common class of drugs that shows dysglycemic effects via interacting with GSK-3 enzyme. Therefore, it is the need of the day to properly understand functions and mechanisms of GSK-3, especially its role in glucose homeostasis via effects on glycogen synthase.
RESUMO
Resumo O diabetes mellitus (DM) é uma doença não transmissível em todo o mundo, na qual existe nível glicêmico persistentemente alto em relação à normalidade. O diabetes e a resistência à insulina são os principais responsáveis ​​pelas morbidades e mortalidades de humanos no mundo. Essa doença é regulada principalmente por várias enzimas e hormônios, entre os quais a glicogênio sintase quinase-3 (GSK-3) é uma enzima principal e a insulina é o principal hormônio que a regula. A GSK-3, que é a enzima-chave, normalmente mostra suas ações por vários mecanismos que incluem sua fosforilação, formação de complexos de proteínas e outras distribuições celulares e, portanto, controla e afeta diretamente a morfologia celular, seu crescimento, mobilidade e apoptose do célula. Perturbações na ação da enzima GSK-3 podem levar a várias condições de doença que incluem resistência à insulina que leva ao diabetes, doenças neurológicas como a doença de Alzheimer e câncer. As fluoroquinolonas são a classe mais comum de drogas que apresentam efeitos disglicêmicos por meio da interação com a enzima GSK-3. Portanto, é necessário hoje em dia compreender adequadamente as funções e mecanismos da GSK-3, principalmente seu papel na homeostase da glicose via efeitos na glicogênio sintase.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Diabetes Mellitus Limits: Humans Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Khyber Medical University/PK / Sarhad University of Science and Information Technology/PK / Shaheed Benazir Bhutto University/PK / Umm Al-Qura University/SA / University of Malakand/PK

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Full text: Available Index: LILACS (Americas) Main subject: Insulin Resistance / Diabetes Mellitus Limits: Humans Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Khyber Medical University/PK / Sarhad University of Science and Information Technology/PK / Shaheed Benazir Bhutto University/PK / Umm Al-Qura University/SA / University of Malakand/PK