Cardiomyopathy and cardiac function in fetuses and newborns of diabetic mothers
J. pediatr. (Rio J.)
;
97(5): 520-524, Sept.-Oct. 2021. tab
Article
in English
| LILACS
| ID: biblio-1340162
ABSTRACT
Abstract Objective:
To evaluate cardiac function and structural changes in children of diabetic mothers in the fetal and neonatal period using Doppler-echocardiographic data.Method:
A prospective, descriptive observational study conducted in a private and tertiary care service for high-risk pregnant women. It included 48 children of mothers with gestational diabetes mellitus (GDM) considered clinically compensated during pregnancy, with a single fetus and absence of malformations. Myocardial thickness, shortening fraction, left ventricular (LVMPI) and right ventricular (RVMPI) myocardial performance index, and mitral and tricuspid valve E/A ratio were evaluated in 96 echocardiographic exams with Doppler.Results:
The hypertrophic cardiomyopathy was 29% vs 6% p = 0.006 in the prenatal and postnatal periods respectively. The shortening fraction was 0% vs 6% p = 0.242 in the fetuses and newborns respectively. The myocardial performance index of the right ventricle was 12% vs 54% p ≤ 0.001, and on the left ventricle 27% vs 60% p = 0.001 in the prenatal and postnatal periods respectively. The ratio of mitral valve E/A waves was 6% vs 50% p ≤ 0.001 and the ratio of tricuspid valve E/A waves was 0% vs 27% p 0.001 in the fetuses and newborns respectively.Conclusion:
A decrease in the rate of myocardial hypertrophy and changes in cardiac function parameters were observed in the fetal and neonatal periods.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Diabetes, Gestational
/
Cardiomyopathies
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Child
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UNIMED Hospital Center/BR
/
Universidade Federal de São Paulo (UNIFESP)/BR
/
Universidade da Região de Joinville (UNIVILLE)/BR
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