Pathologic changes in patients infected with SARS-CoV-2: a review
Afr. J. Clin. Exp. Microbiol
;
22(4): 423-429, 2021.
Article
in English
| AIM
| ID: biblio-1342104
ABSTRACT
Severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2) enters cells using the angiotensin converting enzyme 2 (ACE2), which are expressed by the respiratory tract endothelium, epithelial cells of the stomach, duodenum, ileum, rectum, cholangiocytes, and hepatocytes. Pathological examinations of these organs are not feasible method of diagnosis but can explain pathological changes, pathogenesis of the disease, and the cause of death in COVID-19 cases. In this review, we performed a literature search for COVID-19-related pathological changes seen during post-mortem examinations in different organs of the body including the lungs, gastrointestinal tract, liver, kidney, skin, heart and blood. Our findings showed that SARS-CoV-2 has damaging effects on many organs, probably due to the host immune responses to the presence of the virus. It is recommended that both antiviral and immunomodulatory agents should be considered in the management of COVID-19 patients for better prognosis, and clinical outcome:
Full text:
Available
Index:
AIM (Africa)
Main subject:
Pathology
/
Angiotensin-Converting Enzyme 2
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
Afr. J. Clin. Exp. Microbiol
Year:
2021
Type:
Article
Institution/Affiliation country:
Department of Medical Microbiology and Immunology, Nile University of Nigeria/NG
/
Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University/NG
/
Department of Medical Microbiology and Parasitology, LAUTECH Teaching Hospital/NG
/
Department of Pathology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan/NG
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