Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
Clin. biomed. res
;
41(3): 220-223, 20210000. tab
Article
in English
| LILACS
| ID: biblio-1342397
ABSTRACT
Introduction:
It is well established that cortical volume are decreased in patients with schizophrenia. One possible explanation is that the increased pro-inflammatory status in schizophrenia is related to volumetric decrease of gray matter. The aim of this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with schizophrenia and controls.Methods:
We selected 36 patients with schizophrenia and 35 controls. Interleukin 6 (IL-6) was correlated with cortical volume in patients with schizophrenia and controls.Results:
IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370) in patients, but not in controls (p = 0.235).Discussion:
Our results are in line with previous studies suggesting that chronic inflammatory activation in patients with schizophrenia could be one plausible mechanism that could contribute for the cortical volumetric decrease often seen in this population. However, this cross-sectional study with a small number of patients does not allow us to establish causal relations. (AU)
Full text:
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Index:
LILACS (Americas)
Main subject:
Schizophrenia
/
Cerebral Cortex
/
Interleukin-6
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clin. biomed. res
Journal subject:
Medicine
Year:
2021
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital de Clínicas de Porto Alegre/BR
/
Universidade Federal do Paraná/BR
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