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Cortical volume is inversely correlated with interleukin-6 serum levels in patients with schizophrenia
Polita, Sandra Lermen; Massuda, Raffael; Panizzutti, Bruna; Gama, Clarissa; Duarte, Juliana Avila.
  • Polita, Sandra Lermen; Hospital de Clínicas de Porto Alegre. Departamento de Radiologia e Ressonância Magnética. Porto Alegre. BR
  • Massuda, Raffael; Universidade Federal do Paraná. Departamento de Psiquiatria. Curitiba. BR
  • Panizzutti, Bruna; Hospital de Clínicas de Porto Alegre. Laboratório de Psiquiatria Molecular. Porto Alegre. BR
  • Gama, Clarissa; Hospital de Clínicas de Porto Alegre. Laboratório de Psiquiatria Molecular. Porto Alegre. BR
  • Duarte, Juliana Avila; Hospital de Clínicas de Porto Alegre. Departamento de Radiologia e Ressonância Magnética. Porto Alegre. BR
Clin. biomed. res ; 41(3): 220-223, 20210000. tab
Article in English | LILACS | ID: biblio-1342397
ABSTRACT

Introduction:

It is well established that cortical volume are decreased in patients with schizophrenia. One possible explanation is that the increased pro-inflammatory status in schizophrenia is related to volumetric decrease of gray matter. The aim of this study was to correlate interleukin 6 (IL-6) with cortical volume in patients with schizophrenia and controls.

Methods:

We selected 36 patients with schizophrenia and 35 controls. Interleukin 6 (IL-6) was correlated with cortical volume in patients with schizophrenia and controls.

Results:

IL-6 was negatively correlated with cortical volume (p = 0.027; rho = −0.370) in patients, but not in controls (p = 0.235).

Discussion:

Our results are in line with previous studies suggesting that chronic inflammatory activation in patients with schizophrenia could be one plausible mechanism that could contribute for the cortical volumetric decrease often seen in this population. However, this cross-sectional study with a small number of patients does not allow us to establish causal relations. (AU)
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Cerebral Cortex / Interleukin-6 Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / Universidade Federal do Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schizophrenia / Cerebral Cortex / Interleukin-6 Type of study: Observational study Limits: Adult / Female / Humans / Male Language: English Journal: Clin. biomed. res Journal subject: Medicine Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / Universidade Federal do Paraná/BR