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Early detection of Pre-XDR TB with line probe assay in a high TB burden country
Madukaji, Laura; Okohu, Isaac; Saheed, Usman; Oyedum, Uche; Enagi, Abdullah; Abubakar, Usman; Adedeji, A S; Owolagba, Femi; Ofuche, Eke; Jay Osi, Samuels; Toyin, Jolayemi; Okonkwo, Prosper.
  • Madukaji, Laura; APIN Public Health Initiatives Abuja. Abuja. NG
  • Okohu, Isaac; Bingham University Nigeria. Abuja. NG
  • Saheed, Usman; APIN Public Health Initiatives Abuja. Abuja. NG
  • Oyedum, Uche; Federal University of Technology Minna. Minna. NG
  • Enagi, Abdullah; Federal University of Technology Minna. Minna. NG
  • Abubakar, Usman; Federal University of Technology Minna. Minna. NG
  • Adedeji, A S; Federal University of Technology Minna. Minna. NG
  • Owolagba, Femi; APIN Public Health Initiatives Abuja. Abuja. NG
  • Ofuche, Eke; APIN Public Health Initiatives Abuja. Abuja. NG
  • Jay Osi, Samuels; APIN Public Health Initiatives Abuja. Abuja. NG
  • Toyin, Jolayemi; APIN Public Health Initiatives Abuja. Abuja. NG
  • Okonkwo, Prosper; APIN Public Health Initiatives Abuja. Abuja. NG
Afr. health sci. ; 21(3): 968-974, 2021.
Article in English | AIM | ID: biblio-1342624
ABSTRACT
Background - Worldwide, tuberculosis (TB) is one of the top 10 causes of death. Drug resistant tuberculosis has lately become a major public health problem that threatens progress made in Tuberculosis (TB) care and control worldwide. The aim of this study was to determine the prevalence of Pre-extensive drug resistant TB among MDR TB in North Central of Nigeria. Methods - This study was conducted from October, 2018 to August, 2019 with 150 samples. In Nigeria, guidelines for DR-TB as recommended by WHO is followed. All the samples from the patients who gave their consent were transported to a zonal reference TB laboratory (ZRL). Results - Mean age was 38.6 ± 13.4 years with peak age at 35-44. Out of these 103 samples processed with LPA, 101(98%) were rifampicin resistant and 2 were rifampicin sensitive, 99(96%) were INH resistant and 4 (4%) were INH sensitive, 5(5%) were fluoroquinolone resistant, 98(95%) were fluoroquinolone sensitive, 12 (12%) were Aminoglycoside + Capreomycin resistant, 91(83%) were Aminoglycoside + Capreomycin sensitive. Conclusion - Multidrug resistant TB and its severe forms (Pre-extensive & extensively drug resistant TB) can be detected early with rapid tool- Line Probe Assay rapid and prevented timely by early initiation on treatment.
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Full text: Available Index: AIM (Africa) Main subject: Tuberculosis / Extensively Drug-Resistant Tuberculosis Type of study: Diagnostic study / Practice guideline / Risk factors / Screening study Limits: Humans Language: English Journal: Afr. health sci. Year: 2021 Type: Article Institution/Affiliation country: APIN Public Health Initiatives Abuja/NG / Bingham University Nigeria/NG / Federal University of Technology Minna/NG

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Full text: Available Index: AIM (Africa) Main subject: Tuberculosis / Extensively Drug-Resistant Tuberculosis Type of study: Diagnostic study / Practice guideline / Risk factors / Screening study Limits: Humans Language: English Journal: Afr. health sci. Year: 2021 Type: Article Institution/Affiliation country: APIN Public Health Initiatives Abuja/NG / Bingham University Nigeria/NG / Federal University of Technology Minna/NG