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Inhibition of α-glucosidase, pancreatic lipase, and antioxidant property of Myrcia hatschbachii D. Legrand containing gallic and ellagic acids / Inhibición de la α-glucosidasa, la lipasa pancreática y la propiedad antioxidante de Myrcia hatschbachii D. Legrand que contiene ácidos gálico y elágico
Gatto, Larissa Junqueira; Oliveira, Gustavo Rezende Bellei de; Rech, Katlin Suellen; Moura, Paula Francislaine; Gribner, Caroline; Merino, Francis José Zortéa; Ávila, Suelen; Dias, Josiane de Fatima Gaspari; Miguel, Obdulio Gomes; Miguel, Marilis Dallarmi.
  • Gatto, Larissa Junqueira; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Oliveira, Gustavo Rezende Bellei de; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Rech, Katlin Suellen; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Moura, Paula Francislaine; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Gribner, Caroline; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Merino, Francis José Zortéa; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Ávila, Suelen; Federal University of Paraná. Program in Food and Nutrition. Curitiba. BR
  • Dias, Josiane de Fatima Gaspari; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Miguel, Obdulio Gomes; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
  • Miguel, Marilis Dallarmi; Federal University of Paraná. Program in Pharmaceutical Science. Curitiba. BR
Bol. latinoam. Caribe plantas med. aromát ; 20(3): 226-243, may. 2021. ilus, tab
Article in English | LILACS | ID: biblio-1342815
ABSTRACT
Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, the aim of this work was to investigate the inhibitory activity of α-glucosidase and pancreatic lipase in the crude extract (EBF) and in the ethyl acetate fraction (FFA) of Myrcia hatschbachii, as well as to identify isolated phenolic compounds and to evaluate the antioxidant property and preliminary in vitro toxicity against Artemia salina. EBF (IC50 3.21 µg/mL) and FFA (IC50 1.14 µg/mL) showed inhibitory activity superior to acarbose (IC50 193.65 µg/mL). In addition, they showed inhibitory effects of pancreatic lipase (IC50 556.58 µg/mL for EBF and 532.68 µg/mL for FFA), antioxidant potential, absence of preliminary toxicity and presence of gallic andellagic acids in FFA. The relevant results in the inhibition of α-glucosidase and pancreatic lipase motivate new studies for the development of herbal medicines that assist in the treatment of diabetic patients.
RESUMEN
Varias especies del género Myrcia se han utilizado en la medicina popular para tratar la diabetes. Por lo tanto, el objetivo de este trabajo fue investigar la actividad inhibitoria de la α-glucosidasa y la lipasa pancreática en el extracto crudo (EBF) y en la fracción de acetato de etilo (FFA) de Myrcia hatschbachii, así como identificar compuestos fenólicos aislados y evaluar la propiedad antioxidante y toxicidad in vitro preliminar contra Artemia salina. EBF (IC50 3.21 µg/mL) y FFA (IC50 1.14 µg/mL) mostraron una actividad inhibitoria superior a la acarbosa (IC50 193.65 µg/mL). Además, mostraron efectos inhibitorios de la lipasa pancreática (IC50 556.58 µg/mL para EBF y 532.68 µg/mL para FFA), potencial antioxidante, ausencia de toxicidad preliminar y presencia de ácidos gálico y elágico en FFA. Los resultados relevantes en la inhibición de la α-glucosidasa y la lipasa pancreática motivan nuevos estudios para el desarrollo de medicamentos a base de hierbas que ayudan en el tratamiento de pacientes diabéticos.
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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Myrtaceae / Glycoside Hydrolase Inhibitors / Lipase / Antioxidants Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Myrtaceae / Glycoside Hydrolase Inhibitors / Lipase / Antioxidants Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR