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The study of Yangyinyiqi mixture anti bleomycin-induced pulmonary fibrosis on rats by intervening matrix metalloproteinase-9 and tissue inhibitors of matrix metallopreoteinases-1 / El estudio de la mezcla Yangyinyiqi en fibrosis pulmonar inducida por anti-bleomicina en ratas por intervención en la matriz metaloproteinasa-9 e inhibidores de tejido de matriz metaloproteinasa-1
Wang, Hong; Zhao, Chen-Yu; Zhu, Yong; Zhou, Ji-Pu; Yin, Wen; Li, Zhi-Yong; Yang, Xue-Qing; Qiu, Xin-Ping.
  • Wang, Hong; Beijing Hospital of Traditional Chinese Medicine. Respiratory Department. CN
  • Zhao, Chen-Yu; Institute of Chinese Minority Traditional Medicine,. Minzu University of China. Respiratory Department. CN
  • Zhu, Yong; Beijing Hospital of Traditional Chinese Medicine. Respiratory Department. CN
  • Zhou, Ji-Pu; Beijing Hospital of Traditional Chinese Medicine. Respiratory Department. CN
  • Yin, Wen; Institute of Chinese Minority Traditional Medicine. Minzu University of China. Respiratory Department. CN
  • Li, Zhi-Yong; Institute of Chinese Minority Traditional Medicine. Minzu University of China. Respiratory Department. CN
  • Yang, Xue-Qing; Beijing Hospital of Traditional Chinese Medicine. Shunyi Hospital. Cardiovascular Department. CN
  • Qiu, Xin-Ping; Beijing Hospital of Traditional Chinese Medicine. Shunyi Hospital. Research Department. CN
Bol. latinoam. Caribe plantas med. aromát ; 20(3): 315-323, may. 2021. ilus, tab
Article in English | LILACS | ID: biblio-1343489
Responsible library: CL1.1
ABSTRACT
To investigate effectsof Yangyinyiqi Mixture on pulmonary fibrosis caused by bleomycin. SD ratswere divided randomly into model group(distilled water,1 mL·0.1 kg-1), dexamethasone acetate group (dexamethasone acetate, the dosage was reduced gradually), low-dose group (Yangyinyiqi Mixture, 11 g·kg-1), moderate-dose group (Yangyinyiqi Mixture, 22 g·kg-1), high-dose group (Yangyinyiqi Mixture, 44 g·kg-1) and control group (distilled water, 1 mL·0.1 kg-1). Yangyinyiqi Mixture and dexamethasone acetate were intragastrically administrated. Lung tissue was collected for histopathological examination. Compared with control group, collagen markedly increased and HYP content significantly increased on 7th day in model group (p<0.01). On 28th day, collagen was diffusely deposited, alveolar was destroyed, and HYP content significantly increased (p<0.01). Compared with model group, bleomycin-induced suffering injury caused MMP-9 expression levels to rapidly increase (7and 14 days, p<0.01). TIMP-1 markedly increased (7and 14 days, p<0.01) and stayed at a high level to28th day. Yangyinyiqi Mixture exerted an effect against pulmonary fibrosis, which could involved prevention of collagen deposition through inhibitingMMP-9 and TIMP-1 expression.
RESUMEN
El trabajo investiga los efectos de la mezcla Yangyinyiqi sobre la fibrosis pulmonary causada por bleomicina. Ratas SD se dividieron aleatoriamente en grupo modelo (agua destilada, 1 mL·0.1 kg-1), grupo acetate de dexametasona (acetate de dexametasona, la dosis se redujo gradualmente), grupo de dosis baja (mezcla Yangyinyiqi, 11 g·kg-1), grupo de dosis moderada (mezcla Yangyinyiqi, 22 g·kg-1), grupo de dosis alta (mezcla Yangyinyiqi, 44 g·kg-1) y grupo control (agua destilada, 1 Ml·0.1 kg-1). La mezcla de Yangyinyiqi y el acetate de dexametasona se administraron por vía intragástrica. Se recolectó tejido pulmonary para examen histopatológico. En comparación con el grupo control, el colágeno aumentó notablemente y el contenido de HYP aumentó significativamente el séptimo día en el grupo modelo (p<0.01). El día 28, el colágeno se depositó difusamente, se produjo destrucción alveolar y el contenido de HYP aumento significativamente (p<0.01). En comparación con el grupo modelo, la lesión inducida por bleomicina causó que los niveles de expression de MMP-9 aumentaron rápidamente (7 y 14 días, p<0.01). TIMP-1 aumentó notablemente (7 y 14 días, p<0.01) y se mantuvo en un nivel alto hasta el día 28. La mezcla Yangyinyiqi ejerció un efecto contra la fibrosis pulmonary, lo que podría implicar la prevención del deposito de colágenio mediante la inhibición de la expression de MMP-9 y TIMP-1.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Fibrosis / Drugs, Chinese Herbal / Tissue Inhibitor of Metalloproteinases / Matrix Metalloproteinase 9 Type of study: Observational study Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Hospital of Traditional Chinese Medicine/CN / Institute of Chinese Minority Traditional Medicine/CN / Institute of Chinese Minority Traditional Medicine,/CN

Full text: Available Index: LILACS (Americas) Main subject: Pulmonary Fibrosis / Drugs, Chinese Herbal / Tissue Inhibitor of Metalloproteinases / Matrix Metalloproteinase 9 Type of study: Observational study Limits: Animals Language: English Journal: Bol. latinoam. Caribe plantas med. aromát Journal subject: Botany / Medicine / Plantas Medicinais / Terapias Complementares Year: 2021 Type: Article Affiliation country: China Institution/Affiliation country: Beijing Hospital of Traditional Chinese Medicine/CN / Institute of Chinese Minority Traditional Medicine/CN / Institute of Chinese Minority Traditional Medicine,/CN