Esclerosis múltiple: reacciones adversas a medicamentos en pacientes bajo ley 20850, Hospital Regional de Talca / Multiple sclerosis: adverse drug reactions in patients under law 20850, Hospital Regional de Talca
Rev. méd. Maule
;
36(2): 15-23, dic. 2020. tab
Article
in Spanish
| LILACS
| ID: biblio-1344586
ABSTRACT
INTRODUCTION:
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, which occurs in up to 85% of cases as relapsing remitting (RR), with episodes of neurological dysfunction partially forwarded. Its treatment in Chile is financially protected by the Explicit Health Guarantees (GES) and Law 20,850 on high-cost diseases. The Regional Hospital of Talca (HRT) has 25 patients benefiting from Law 20,850 in treatment with second-line biologic therapy. Adverse reactions (RAM) to the use of these drugs have been described and to date there are no case reports or studies of significant adverse events in Chile.Objectives:
To present the experience of the use of biologic therapy in EMRR in HRT, in relation to adverse events.METHODS:
A review of the current guidelines in Chile for the treatment of relapsing-remitting multiple sclerosis and the protocol of law 20,850 was carried out, the clinical records of 25 patients benefiting from the law in the HRT were reviewed, with emphasis on the adverse events presented before First and second line therapies and the con sequences of these events on the continuity of therapy.RESULTS:
Half of the patients who started their treatment with first-line drugs had adverse effects, of which 28% involved a change in therapy, the remaining changed from therapy due to failure to treatment. Of the 26 patients included in the sample, 24 are currently using second-line drugs. The profile of adverse effects should be a variable to consider when indicating a therapy for MS.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Multiple Sclerosis
Type of study:
Practice guideline
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Maule
Journal subject:
Medicine
Year:
2020
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Regional de Talca/CL
/
Pontificia Universidad Católica de Chile/CL
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