Growth hormone-releasing hormone-secreting pulmonary neuroendocrine tumor associated with pituitary hyperplasia and somatotropinoma
Arch. endocrinol. metab. (Online)
;
65(5): 648-663, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1345192
ABSTRACT
SUMMARY Acromegaly caused by ectopic growth hormone-releasing hormone (GHRH)-secreting tumor is exceedingly rare. We report a case of acromegaly secondary to GHRH secretion by an incidentally diagnosed pulmonary neuroendocrine tumor (NET) and review 47 similar cases in literature. A 22-year-old male patient presented with symptoms of pituitary apoplexy. Magnetic resonance imaging (MRI) showed apoplexy of a pituitary adenoma. Routinely prior to surgery, a chest radiography was performed which revealed a mass in the left lung. During investigation, the patient was diagnosed with metastatic GHRH-secreting pulmonary NET. In retrospect, it was noted that the patient had pituitary hyperplasia 20 months prior to the MRI which showed the presence of a pituitary adenoma. The histological findings confirmed somatotroph hyperplasia adjacent to somatotropinoma. This case suggests that GHRH secretion can be associated with pituitary hyperplasia, which may be followed by pituitary adenoma formation.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pituitary Neoplasms
/
Acromegaly
/
Adenoma
/
Carcinoma, Neuroendocrine
Type of study:
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Arch. endocrinol. metab. (Online)
Journal subject:
Endocrinology
/
Metabolism
Year:
2021
Type:
Article
Affiliation country:
Brazil
/
Spain
Institution/Affiliation country:
Hospital Universitário Clementino Fraga Filho/BR
/
Instituto Estadual do Cérebro Paulo Niemeyer/BR
/
Instituto Maimónides de Pesquisas Biomédicas de Córdoba/ES
Similar
MEDLINE
...
LILACS
LIS