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Stoichioproteomics study of differentially expressed proteins and pathways in head and neck cancer / Estudo estequioproteômico de proteínas e vias expressas diferencialmente no câncer de cabeça e pescoço
Lan, Y; Liang, Y; Xiao, X; Shi, Y; Zhu, M; Meng, C; Yang, S; Khan, M T; Zhang, Y J.
  • Lan, Y; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Liang, Y; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Xiao, X; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Shi, Y; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Zhu, M; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Meng, C; Chongqing Normal University. College of Life Sciences. Shapingba. CN
  • Yang, S; Ningxia University. School of Life Sciences. Yinchuan. CN
  • Khan, M T; The University of Lahore-Pakistan. Institute of Molecular Biology and Biotechnology. Lahore. PK
  • Zhang, Y J; Chongqing Normal University. College of Life Sciences. Shapingba. CN
Braz. j. biol ; 83: e249424, 2023. graf
Article in English | LILACS, VETINDEX | ID: biblio-1345538
ABSTRACT
Abstract Hypoxia is a prominent feature of head and neck cancer. However, the oxygen element characteristics of proteins and how they adapt to hypoxia microenvironments of head and neck cancer are still unknown. Human genome sequences and proteins expressed data of head and neck cancer were retrieved from pathology atlas of Human Protein Atlas project. Then compared the oxygen and carbon element contents between proteomes of head and neck cancer and normal oral mucosa-squamous epithelial cells, genome locations, pathways, and functional dissection associated with head and neck cancer were also studied. A total of 902 differentially expressed proteins were observed where the average oxygen content is higher than that of the lowly expressed proteins in head and neck cancer proteins. Further, the average oxygen content of the up regulated proteins was 2.54% higher than other. None of their coding genes were distributed on the Y chromosome. The up regulated proteins were enriched in endocytosis, apoptosis and regulation of actin cytoskeleton. The increased oxygen contents of the highly expressed and the up regulated proteins might be caused by frequent activity of cytoskeleton and adapted to the rapid growth and fast division of the head and neck cancer cells. The oxygen usage bias and key proteins may help us to understand the mechanisms behind head and neck cancer in targeted therapy, which lays a foundation for the application of stoichioproteomics in targeted therapy and provides promise for potential treatments for head and neck cancer.
RESUMO
Resumo A hipóxia é uma característica proeminente do câncer de cabeça e pescoço. No entanto, as características do elemento oxigênio das proteínas e como elas se adaptam aos microambientes de hipóxia do câncer de cabeça e pescoço ainda são desconhecidas. Sequências do genoma humano e dados expressos de proteínas de câncer de cabeça e pescoço foram recuperados do atlas de patologia do projeto Human Protein Atlas. Em seguida, comparou o conteúdo do elemento de oxigênio e carbono entre proteomas de câncer de cabeça e pescoço, e células epiteliais escamosas da mucosa oral normal, localizações do genoma, vias e dissecção funcional associada ao câncer de cabeça e pescoço também foram estudadas. Um total de 902 proteínas expressas diferencialmente foi observado onde o conteúdo médio de oxigênio é maior do que as proteínas expressas de forma humilde em proteínas de câncer de cabeça e pescoço. Além disso, o conteúdo médio de oxigênio das proteínas reguladas positivamente foi 2,54% maior do que das outras. Nenhum de seus genes codificadores foi distribuído no cromossomo Y. As proteínas reguladas positivamente foram enriquecidas em endocitose, apoptose e regulação do citoesqueleto de actina. O conteúdo aumentado de oxigênio das proteínas altamente expressas e reguladas pode ser causado pela atividade frequente do citoesqueleto e adaptado ao rápido crescimento e divisão das células cancerosas de cabeça e pescoço. O viés do uso de oxigênio e as proteínas-chave podem nos ajudar a entender os mecanismos por trás do câncer de cabeça e pescoço na terapia direcionada, o que estabelece uma base para a aplicação da estequioproteômica na terapia direcionada e oferece uma promessa para potenciais tratamentos para o câncer de cabeça e pescoço.
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Full text: Available Index: LILACS (Americas) Main subject: Head and Neck Neoplasms Limits: Humans Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Chongqing Normal University/CN / Ningxia University/CN / The University of Lahore-Pakistan/PK

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Full text: Available Index: LILACS (Americas) Main subject: Head and Neck Neoplasms Limits: Humans Language: English Journal: Braz. j. biol Year: 2023 Type: Article Institution/Affiliation country: Chongqing Normal University/CN / Ningxia University/CN / The University of Lahore-Pakistan/PK